Characterization of mechanical properties of pericardium tissue using planar biaxial tension and flexural deformation.
Characterization of mechanical properties of pericardium tissue using planar biaxial tension and flexural deformation.
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DOI：
10.1016/j.jmbbm.2017.08.039
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发表时间：
2018-01
影响因子：
3.9
通讯作者：
Sun W
中科院分区：
文献类型：
--
作者：
Murdock K;Martin C;Sun W
弯曲是自体和生物心脏瓣膜的重要变形模式。然而，生物瓣叶材料的机械表征主要通过平面拉伸试验完成。在本研究中，进行了综合实验和计算的悬臂梁弯曲测试，以表征不同厚度的经戊二醛处理的牛和猪心包的弯曲性能。使用基于应变不变的结构本构模型来模拟通过本研究的弯曲试验和先前进行的平面双轴试验量化的心包机械行为。模型参数进行了优化，通过逆有限元（FE）程序，以描述两组实验数据。在经导管主动脉瓣（TAV）变形的有限元模拟中实现了优化的材料特性。据观察，在接受开放加压时，猪心包TAV瓣叶的弯曲程度明显高于牛心包TAV瓣叶，并且使用从纯平面拉伸实验数据推导出的本构模型可能会高估弯曲程度。因此，可能需要对弯曲和双轴拉伸试验数据的组合进行建模，以更准确地描述心包的机械性能，并通过计算研究生物瓣叶功能和设计。
Flexure is an important mode of deformation for native and bioprosthetic heart valves. However, mechanical characterization of bioprosthetic leaflet materials has been done primarily through planar tensile testing. In this study, an integrated experimental and computational cantilever beam bending test was performed to characterize the flexural properties of glutaraldehyde-treated bovine and porcine pericardium of different thicknesses. A strain-invariant based structural constitutive model was used to model the pericardial mechanical behavior quantified through the bending tests of this study and the planar biaxial tests previously performed. The model parameters were optimized through an inverse finite element (FE) procedure in order to describe both sets of experimental data. The optimized material properties were implemented in FE simulations of transcatheter aortic valve (TAV) deformation. It was observed that porcine pericardium TAV leaflets experienced significantly more flexure than bovine when subjected to opening pressurization, and that the flexure may be overestimated using a constitutive model derived from purely planar tensile experimental data. Thus, modeling of a combination of flexural and biaxial tensile testing data may be necessary to more accurately describe the mechanical properties of pericardium, and to computationally investigate bioprosthetic leaflet function and design.
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影响因子：
3.5
作者：
Martin, Caitlin;Sun, Wei
通讯作者：
Sun, Wei
影响因子：
14
作者：
Engelmayr, GC;Hildebrand, DK;Sacks, MS
通讯作者：
Sacks, MS
影响因子：
14
作者：
Mirnajafi, A;Raymer, J;Sacks, MS
通讯作者：
Sacks, MS
DOI：
10.1002/jbm.820220202
发表时间：
1988-02-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
CROFTS, CE;TROWBRIDGE, EA
通讯作者：
TROWBRIDGE, EA
影响因子：
2
作者：
Holzapfel, GA;Gasser, TC;Ogden, RW
通讯作者：
Ogden, RW