Simulation of long-term fatigue damage in bioprosthetic heart valves: effects of leaflet and stent elastic properties.
Simulation of long-term fatigue damage in bioprosthetic heart valves: effects of leaflet and stent elastic properties.
复制标题
DOI：
10.1007/s10237-013-0532-x
复制
发表时间：
2014-08
影响因子：
3.5
通讯作者：
Sun, Wei
中科院分区：
文献类型：
--
作者：
Martin, Caitlin;Sun, Wei
生物人工心脏瓣膜（BHV）的主要失效模式之一是由于组织小叶疲劳导致的非钙化结构恶化；然而，疲劳的机制尚不清楚。 BHV 耐用性主要根据加速磨损测试后对小叶的目视检查进行评估。在这项研究中，我们开发了一个计算框架来模拟 BHV 小叶疲劳，该框架既高效又定量，使其成为传统加速磨损测试的有吸引力的替代方案。我们利用先前开发的现象学软组织疲劳损伤模型来描述 BHV 中经戊二醛处理的牛心包小叶在循环载荷作用下的应力软化和永久变形。进行参数研究以确定改变小叶和支架弹性特性对小叶疲劳的影响。模拟结果表明，小叶弹性特性的异质性、小叶接合不良和支架尖端偏转较小可能会加速小叶疲劳，这与临床结果一致。因此，所开发的框架可能是评估新组织瓣膜设计（包括传统 BHV 和新型经导管瓣膜）中小叶耐久性的宝贵工具。
One of the major failure modes of bioprosthetic heart valves (BHVs) is noncalcific structural deterioration due to fatigue of the tissue leaflets; yet, the mechanisms of fatigue are not well understood. BHV durability is primarily assessed based on visual inspection of the leaflets following accelerated wear testing. In this study, we developed a computational framework to simulate BHV leaflet fatigue, which is both efficient and quantitative, making it an attractive alternative to traditional accelerated wear testing. We utilize a phenomenological soft tissue fatigue damage model developed previously to describe the stress softening and permanent set of the glutaraldehyde-treated bovine pericardium leaflets in BHVs subjected to cyclic loading. A parametric study was conducted to determine the effects of altered leaflet and stent elastic properties on the fatigue of the leaflets. The simulation results show that heterogeneity of the leaflet elastic properties, poor leaflet coaptation, and little stent-tip deflection may accelerate leaflet fatigue, which agrees with clinical findings. Therefore, the developed framework may be an invaluable tool for evaluating leaflet durability in new tissue valve designs, including traditional BHVs as well as new transcatheter valves.
登录
查看更多内容
影响因子：
4.9
作者：
Martin, Caitlin;Sun, Wei
通讯作者：
Sun, Wei
影响因子：
4.6
作者：
BRAIS, MP;BEDARD, JP;KEON, WJ
通讯作者：
KEON, WJ
影响因子：
4.6
作者：
NISTAL, F;ARTINANO, E;GALLO, I
通讯作者：
GALLO, I
影响因子：
3.5
作者：
Sun, W;Sacks, MS
通讯作者：
Sacks, MS
影响因子：
3.4
作者：
CHRISTIE, GW
通讯作者：
CHRISTIE, GW