Neural mechanisms of abnormal sensations after nerve injury
Neural mechanisms of abnormal sensations after nerve injury
复制标题
神经损伤后感觉异常的神经机制
DOI：
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
J. Campbell
中科院分区：
文献类型：
--
作者：
R. Meyer;G. Koschorke;D. Tillman;J. Campbell
神经受伤的患者经常报告说，敲击受伤部位会在神经的原始区域产生刺痛感。灵长类动物单个神经纤维的记录表明，在神经纤维再生过程中神经损伤后，会对机械刺激产生敏感性。这种敏感性可能解释了患者所报告的感觉。对再生纤维施加振动刺激以确定其频率响应特性。根据纤维的响应，纤维分为三种类型：（1）纤维对低于 5 Hz 的频率最敏感； (2) 对中频（1050 Hz）最敏感的纤维； (3) 纤维对大于 100 Hz 的频率最敏感。这些反应与皮肤中负责触觉的正常机械感受器的反应相似。根据这些结果，我们提出了一种机制来解释受伤神经纤维中机械敏感性的发展。
Patients with injured nerves often report that tapping at the site of injury produces tingling sensations in the original territory of the nerve. Recordings from single nerve fibers in primates indicate that a sensitivity to mechanical stimuli develops after a nerve injury at regenerating nerve fibers; this sensitivity likely accounts for the sensations reported by patients. Vibratory stimuli were applied to regenerating fibers to determine their frequency-response properties. Fibers were grouped into three types, based on their responses: (1) fibers most sensitive to frequencies less than 5 Hz; (2) fibers most sensitive to middle frequencies (1050 Hz); and (3) fibers most sensitive to frequencies greater than 100 Hz. These responses are similar to those of normal mechanoreceptors in the skin responsible for touch sensation. On the basis of these results, we propose a mechanism that explains the development of mechanosensitivity in injured nerve fibers.
猴子受伤神经的异位兴奋性：对振动刺激的夹带反应。
影响因子：
2.5
作者：
Koschorke,GM;Meyer,RA;Tillman,DB;Campbell,JN
通讯作者：
Campbell,JN
影响因子：
2.5
作者：
BOLANOWSKI, SJ
通讯作者：
BOLANOWSKI, SJ