The hemorphins: a new class of opioid peptides derived from the blood protein hemoglobin.
The hemorphins: a new class of opioid peptides derived from the blood protein hemoglobin.
复制标题
海吗啡：源自血液蛋白血红蛋白的一类新型阿片肽。
作者：
F. Nyberg;K. Sanderson;E. Glämsta
内啡肽是属于“非经典”或“非典型”阿片肽家族的内源性肽。它们是由血液蛋白血红蛋白的β-、κ-、δ-或ε-链的酶水解产生的。最初，从酶处理过的牛血中分离出血红素。近年来，已鉴定出脑、血浆和脑脊液中天然存在的肽类结构。本文将综述近年来有关其结构、释放机制及其生物学作用的研究。一个特别的重点将是针对他们的作用，行使人类和他们的临床相关性。
Hemorphins are endogenous peptides belonging to the family of "nonclassical" or "atypical" opioid peptides. They are generated by enzymatic hydrolysis of the beta-, kappa-, delta-, or epsilon-chain of the blood protein hemoglobin. Originally, the hemorphins were isolated from enzymatically treated bovine blood. In recent years hemorphin structures have been identified as naturally occurring peptides in brain, plasma, and cerebrospinal fluid. This article will review recent studies of the hemorphins regarding their structures, mechanisms for their release, and their biological actions. A particular emphasis will be directed to their role in exercising human and their clinical relevance.
DOI：
10.1073/pnas.90.14.6736
发表时间：
1993-07
影响因子：
11.1
作者：
K. Yasuda;K. Raynor;H. Kong;C. Breder;J. Takeda;T. Reisine;G. Bell
通讯作者：
K. Yasuda;K. Raynor;H. Kong;C. Breder;J. Takeda;T. Reisine;G. Bell
影响因子：
4.1
作者：
Thoren,P;Floras,JS;Hoffmann,P;Seals,DR
通讯作者：
Seals,DR
影响因子：
56.9
作者：
EVANS, CJ;KEITH, DE;EDWARDS, RH
通讯作者：
EDWARDS, RH