New perspectives on an ancient pathogen: thoughts for World Tuberculosis Day 2022.
New perspectives on an ancient pathogen: thoughts for World Tuberculosis Day 2022.
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一种古老病原体的新视角：2022年世界结核病日的思考。
DOI：
10.1099/mic.0.001178
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发表时间：
2022-03
期刊：
影响因子：
2.8
通讯作者：
Beste, Dany J. V.
中科院分区：
文献类型：
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作者：
Beste, Dany J. V.
上一次致力于分枝杆菌的特别版是在2003年，重点关注后基因组时代在分枝杆菌研究方面取得重大进展的前景[1]。在接下来的几十年里，我们对这一重要细菌群体的基本生物学有了更深入的了解。下一代测序彻底改变了我们对分枝杆菌进化动力学的认识，包括耐药性的发展[2]。在结核病诊断和控制措施方面也有创新，包括新的抗生素，从而减少了这种疾病的病例和死亡率。然而，令人遗憾的是，结核病控制措施的中断一直是2019年冠状病毒病(新冠肺炎)大流行的附带损害之一，2020年，我们看到结核病死亡人数十多年来首次增加[3]。预计这将使世界卫生组织(WHO)将全球结核病负担减少约12年的战略倒退[4]。分枝杆菌研究仍然资金严重不足，非结核分枝杆菌感染正在上升，牛分枝杆菌仍然是全球牛和人畜共患结核病的主要原因。尽管存在这些障碍，分枝杆菌研究人员仍在继续开展令人兴奋的尖端研究，这一点在本期《微生物学》特刊中可见一斑。分枝杆菌研究人员在病理代谢和免疫代谢的新兴前沿领域走在了前列。我们现在更好地了解了这种病原体在其人类宿主内生长时的饮食需求，以及结核分枝杆菌是如何影响其宿主的新陈代谢和免疫的。现在，人们的注意力被重新引向了解宿主病原体相互作用期间对金属离子的争夺。了解分枝杆菌对金属的获取以及宿主如何将金属用作抑菌/杀菌武器是Serafini和Tamuhla等人的一项研究的重点。Serafini回顾了我们对中枢碳代谢和金属动态平衡之间相互作用的有限知识，以及这如何导致抗结核病药物的开发[5]。Tamuhla和他的同事定义了污垢分枝杆菌适应低铁胁迫的新遗传机制[6]。
The last special edition dedicated to mycobacteria was in 2003 and focused on the promise of the post-genomic era to deliver significant advances in mycobacterial research [1]. In the intervening decades we have advanced our understanding about the basic biology of this important group of bacteria. Next-generation sequencing has revolutionized our knowledge of the evolutionary dynamics of mycobacteria, including the development of drug resistance [2]. There have also been innovations in terms of tuberculosis (TB) diagnostics and control measures, including new antibiotics, which have translated into a reduction in cases and death rates from this disease. However, disruption of TB control measures has sadly been amongst the collateral damage of the coronavirus disease 2019 (COVID-19) pandemic, and in 2020 we saw the first increase in TB deaths recorded for over a decade [3]. This is predicted to setback the World Health Organization’s (WHO’s) strategy for reducing the global burden of TB by~ 12 years [4]. Mycobacterial research remains massively underfunded, non-TB mycobacterial infections are on the rise and Mycobacterium bovis remains a dominant cause of bovine and zoonotic TB worldwide. Despite these impediments, mycobacterial researchers continue to deliver exciting and cutting-edge research, as exemplified in this special issue of Microbiology.Mycobacterial researchers have led the way in the emerging frontiers of pathometabolism and immunometabolism. We now have a much better understanding of the dietary requirements of this pathogen when it is growing within its human host [2] and how M. tuberculosis affects its host’s metabolism and immunity. Attention is now being redirected to understanding the battle for metal ions during host pathogen interactions. Understanding metal acquisition by mycobacteria and how metals are used by the host as bacteriostatic/bactericidal weapons is the focus of a review by Serafini and a study by Tamuhla et al.[5, 6]. Serafini reviews our limited knowledge of the interplay between central carbon metabolism and metal homeostasis and how this could lead to the development of anti-TB drugs [5]. Tamuhla and colleagues defined new genetic mechanisms by which M. smegmatis adapts to low iron stress [6].
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DOI：
10.1099/mic.0.000952
发表时间：
2020-09
期刊：
Microbiology (Reading, England)
影响因子：
--
作者：
Pickford H;Alcock E;Singh A;Kelemen G;Bhatt A
通讯作者：
Bhatt A
影响因子：
2.8
作者：
Singh, Shweta;Godavarthi, Sapna;Sen, Ranjan
通讯作者：
Sen, Ranjan
影响因子：
2.8
作者：
Di Capua, Cecilia B.;Belardinelli, Juan M.;Morbidoni, Hector R.
通讯作者：
Morbidoni, Hector R.
影响因子：
2.8
作者：
Fowler, Philip W.;Cruz, Ana Luiza Gibertoni;Crook, Derrick W.
通讯作者：
Crook, Derrick W.
影响因子：
2.8
作者：
Chatterjee, Ayan;Sharma, Arun Kumar;Kundu, Manikuntala
通讯作者：
Kundu, Manikuntala