Composite mandibulectomy: a novel animal model.
Composite mandibulectomy: a novel animal model.
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DOI：
10.1177/0194599811435633
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发表时间：
2012-06
期刊：
影响因子：
--
通讯作者：
St John MA
中科院分区：
文献类型：
--
作者：
Sidell DR;Aghaloo T;Tetradis S;Lee M;Bezouglaia O;DeConde A;St John MA
下颌骨节段性缺损可在各种病理过程治疗后产生，包括放射性骨坏死、肿瘤切除或骨折不愈合伴隔离症。下颌骨节段性缺损的发生率和病因的多样性使其重建成为一个重要的研究课题。尽管有这些刺激因素，但尚不存在一个完善的下颌骨节段性切除术（包括复合切除术）的小动物模型。本研究的目的是建立一个可靠的动物模型，可用于研究下颌骨整体缺损的重建。手术技术和一系列重建的选择进行了说明。动物模型的描述。四级护理大学医学中心的动物实验室。我们提出了一个动物研究监督委员会批准的前瞻性分析的生存操作的大鼠模型。详细、逐步描述了手术技术和相关术中解剖结构。术后管理，早期陷阱，手术并发症，和未来的应用进行了讨论。2010年7月至10月期间，一个人共做了72例手术。发现2例术中和9例术后并发症。口瘘6例，脓肿2例，血清肿1例。有4例死亡，归因于麻醉并发症（2例，术中）、血肿形成（1例，术后）和异物吸入（1例，术后）。这种新的动物模型可靠地复制了我们的患者群体中所见的整体节段性下颌骨缺损，并且可以被操纵以实现各种各样的研究目标。
Segmental mandibular defects can result after the treatment of various pathologic processes, including osteoradionecrosis, tumor resection, or fracture nonunion with sequestration. The variety of etiologies and the frequency of occurrence make the reconstruction of segmental mandibular defects a topic of significant interest. Despite these incentives, a well-established small-animal model of the segmental mandibulectomy, including composite resection, does not exist. The objective of this study is the creation of a reliable animal model that can be used to study the reconstruction of en bloc mandibular defects. Surgical techniques and an array of reconstructive options are described. Description of an animal model. Animal laboratory at a quaternary care university medical center. We present an Animal Research Oversight Committee–approved prospective analysis of survival operations in the rat model. A detailed, stepwise description of surgical technique and relevant intraoperative anatomy is presented. Postoperative management, early pitfalls, surgical complications, and future applications are discussed. A total of 72 operations were performed by a single individual between July and October 2010. Two intraoperative and 9 postoperative complications were recognized. There were 6 orocutaneous fistulas, 2 abscesses, and 1 seroma. There were 4 fatalities, which were attributed to anesthetic complications (2, intraoperative), hematoma formation (1, postoperative), and foreign-body aspiration (1, postoperative). This novel animal model reliably replicates the en bloc segmental mandibular defects seen in our patient population and can be manipulated to achieve a wide variety of research objectives.
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