Reactivation of networks involved in preparatory states.

Reactivation of networks involved in preparatory states.
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重新激活参与准备状态的网络。

DOI:
10.1093/cercor/12.6.590
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发表时间:
2002
期刊:
Cerebral cortex (New York, N.Y. : 1991)
影响因子:
--
通讯作者:
Corbetta,Maurizio
Corbetta,Maurizio
中科院分区:
--
文献类型:
--
作者:
Shulman,GordonL;Tansy,AaronP;Kincade,Michelle;Petersen,StevenE;McAvoy,MarkP;Corbetta,Maurizio

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We report an endogenous signal that has a widespread cortical distribution and is time-locked to the termination of a sustained state of task-readiness. In three event-related functional magnetic resonance imaging (fMRI) experiments, subjects saw an arrow cue that predicted either the direction of motion or the location of a subsequent test stimulus. A reactivation of the BOLD (blood oxygenation level-dependent) signal occurred at the termination of the state of readiness in occipital regions that were transiently activated by the cue and in frontal-parietal regions that maintained an attentional set over the trial. Moreover, a delayed activation occurred in prefrontal and temporo-parietal regions that did not initially respond to the cue and that have been implicated in re-orienting attention to novel sensory events. These latter regions may have generated control signals that ended the state of readiness in regions active during the cue period. These results indicate that terminating a state of readiness produces a widely distributed cortical signal and suggest that areas involved in a preparatory state may be maintained as a network which can be modulated as a whole.
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