Reticulate acropigmentation of Kitamura with a novel mutation in ADAM10

Reticulate acropigmentation of Kitamura with a novel mutation in ADAM10
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ADAM10 中出现新突变的 Kitamura 的网状肢端色素沉着

DOI:
10.1111/ced.13832
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发表时间:
2018-11
影响因子:
4.1
通讯作者:
Lin Z
Lin Z
中科院分区:
医学4区
文献类型:
--
作者:
Pan Y;Zhong W;Wang H;Yang Y;Lin Z

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pulsatile erythematous plaque, thought to be caused by an insect bite, over her right buttock and thigh. Results of echocardiography, Doppler USS and blood investigations were normal. She was treated with prednisolone and topical steroids and the plaque resolved 2 weeks later. Lazar et al. reported a case of a blinking lesion in a 30-year-old woman, which was also believed to be attributable to insect bites. The blinking resolved after 24 h and the patient recovered uneventfully. We believe that the pathogenesis of Quincke sign is due to chemical mediator release from insect bites, which leads to local arterial dilatation and subsequently arteriole insufficiency in maintaining adequate pressure during diastole, resulting in the distinctive alternating pattern of blanching and flushing in rhythm with arterial pulsation. In conclusion, this was an unusual case of multiple blinking erythematous lesions caused by insect bites affecting the legs, arms and buttocks of a healthy child. This case strengthens the evidence that Quincke sign can occur in healthy people and is not just confined to the nail bed.
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