Design, synthesis, and evaluation of inhibitors of Norwalk virus 3C protease.
Design, synthesis, and evaluation of inhibitors of Norwalk virus 3C protease.
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DOI：
10.1016/j.bmcl.2011.07.016
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发表时间：
2011-09-15
影响因子：
2.7
通讯作者：
Groutas, William C.
中科院分区：
文献类型：
--
作者：
Tiew, Kok-Chuan;He, Guijia;Aravapalli, Sridhar;Mandadapu, Sivakoteswara Rao;Gunnam, Mallikarjuna Reddy;Alliston, Kevin R.;Lushington, Gerald H.;Kim, Yunjeong;Chang, Kyeong-Ok;Groutas, William C.
The first series of peptidyl aldehyde inhibitors that incorporate in their structure a glutamine surrogate has been designed and synthesized based on the known substrate specificity of Norwalk virus 3C protease. The inhibitory activity of the compounds with the protease and with a norovirus cell-based replicon system was investigated. Members of this class of compounds exhibited noteworthy activity both in vitro and in a cell-based replicon system.
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影响因子：
7.3
作者：
Dragovich, PS;Prins, TJ;Worland, ST
通讯作者：
Worland, ST
影响因子：
5
作者：
Hardy, ME;Crone, TJ;Ettayebi, K
通讯作者：
Ettayebi, K
影响因子：
3.5
作者：
Bogen, Stephane L.;Arasappan, Ashok;Njoroge, F. George
通讯作者：
Njoroge, F. George
影响因子：
3.7
作者：
Blakeney, SJ;Cahill, A;Reilly, PA
通讯作者：
Reilly, PA
DOI：
10.1056/nejmra0804575
发表时间：
2009-10-29
期刊：
The New England journal of medicine
影响因子：
--
作者：
Glass RI;Parashar UD;Estes MK
通讯作者：
Estes MK