Epicardium-derived cells (EPDCs) in development, cardiac disease and repair of ischemia.
Epicardium-derived cells (EPDCs) in development, cardiac disease and repair of ischemia.
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DOI：
10.1111/j.1582-4934.2010.01077.x
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发表时间：
2010-05
影响因子：
5.3
通讯作者：
Poelmann RE
中科院分区：
文献类型：
--
作者：
Gittenberger-de Groot AC;Winter EM;Poelmann RE
心外膜原源性心外膜覆盖心肌，经过上皮-间质转化（EMT）形成心外膜源性细胞（EPDCs）。这些细胞迁移到心肌中，并在心室致密心肌的诱导和浦肯野纤维的分化中发挥重要作用。EPDCs还是间质成纤维细胞、冠状动脉平滑肌细胞和内皮成纤维细胞的来源。在心脏干细胞生态位中分化为心肌细胞、内皮细胞和最近描述的远端细胞和其他细胞的可能性需要进一步研究。手术或遗传干扰心外膜和EPDC分化可导致一系列异常，从薄的未分化心肌（可致胚胎死亡）到冠状动脉血管床缩小，甚至冠状动脉主动脉缺失。epdc的胚胎潜能已被转化为结构和功能先天性畸形以及成人心脏病，如Ebstein畸形、心律失常和心肌病的发展。此外，研究人员还对成体EPDCs作为干细胞来源进行了探索，结果显示，在心肌缺血的动物模型中，胚胎程序的再现具有改善的功能、血管生成和更少的不良重构。EPDCs与成人心肌祖细胞联合使用可协同改善这些结果。注射epdc的贡献是指导性的，而不是建设性的。内源性心外膜在缺血时的再激活与发育基因的重新表达和EMT的更新标志着一个新的治疗焦点的开始。
The proepicardial-derived epicardium covers the myocardium and after a process of epithelial–mesenchymal transition (EMT) forms epicardium-derived cells (EPDCs). These cells migrate into the myocardium and show an essential role in the induction of the ventricular compact myocardium and the differentiation of the Purkinje fibres. EPDCs are furthermore the source of the interstitial fibroblast, the coronary smooth muscle cell and the adventitial fibroblast. The possible differentiation into cardiomyocytes, endothelial cells and the recently described telocyte and other cells in the cardiac stem cell niche needs further investigation. Surgically or genetically disturbed epicardial and EPDC differentiation leads to a spectrum of abnormalities varying from thin undifferentiated myocardium, which can be embryonic lethal, to a diminished coronary vascular bed with even absent main coronary arteries. The embryonic potential of EPDCs has been translated to both structural and functional congenital malformations and adult cardiac disease, like development of Ebstein’s malformation, arrhythmia and cardiomyopathies. Furthermore, the use of adult EPDCs as a stem cell source has been explored, showing in an animal model of myocardial ischemia the recapitulation of the embryonic program with improved function, angiogenesis and less adverse remodeling. Combining EPDCs and adult cardiomyocyte progenitor cells synergistically improved these results. The contribution of injected EPDCs was instructive rather than constructive. The finding of reactivation of the endogenous epicardium in ischemia with re-expression of developmental genes and renewed EMT marks the onset of a novel therapeutic focus.
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影响因子：
2.7
作者：
Zhou, Bin;von Gise, Alexander;Ma, Qing;Hu, Yong Wu;Pu, William T.
通讯作者：
Pu, William T.
影响因子：
5.2
作者：
van Tuyn, John;Atsma, Douwe E.;de Vries, Antoine A. F.
通讯作者：
de Vries, Antoine A. F.
影响因子：
2.7
作者：
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通讯作者：
Rosenthal, N
影响因子：
37.8
作者：
Winter, E. M.;Grauss, R. W.;Gittenberger-de Groot, A. C.
通讯作者：
Gittenberger-de Groot, A. C.
影响因子：
64.8
作者：
Zhou, Bin;Ma, Qing;Pu, William T.
通讯作者：
Pu, William T.