Association between high-sensitivity C-reactive protein and N-Terminal Pro-B-Type Natriuretic Peptide in patients with hepatitis C virus infection.
Association between high-sensitivity C-reactive protein and N-Terminal Pro-B-Type Natriuretic Peptide in patients with hepatitis C virus infection.
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DOI：
10.1155/2012/730923
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发表时间：
2012
影响因子：
4.6
通讯作者：
Hu D
中科院分区：
文献类型：
--
作者：
Che W;Zhang B;Liu W;Wei Y;Xu Y;Hu D
Background. Prior study showed HCV-infected patients have increased serum N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) and a possible left ventricular diastolic dysfunction. The objectives of the present paper were to investigate the characteristics of hs-CRP and its correlation with clinical profiles including NT-proBNP and echocardiographic variables in HCV-infected patients. Methods and Results. A total of 106 HCV-infected patients and 106 control healthy individuals were enrolled. The level of serum hs-CRP (median 1.023 mg/L, range 0.03∼5.379 mg/L) was significantly lower in all 106 patients than that in controls (median 3.147 mg/L, range 0.08~7.36 mg/L, P = 0.012). Although hs-CRP did not correlate significantly with NT-proBNP when all patients and controls were included (r = 0.169, P = 0.121), simple regression analysis demonstrated a statistically significant linear correlation between hs-CRP and NT-proBNP in HCV-infected patients group (r = 0.392, P = 0.017). Independent correlates of hs-CRP levels (R 2 = 0.13) were older age (β′ = 0.031, P = 0.025) and NT proBNP (β′ = 0.024, P = 0.017). Conclusions. Although the level of serum hs-CRP decreased significantly, there was a significant association between hs-CRP and NT-proBNP in HCV-infected patients.
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DOI：
10.20452/pamw.1001
发表时间：
2010-12-01
影响因子：
--
作者：
Skowronski, Marcin;Zozulinska-Ziolkiewicz, Dorota;Wierusz-Wysocka, Bogna
通讯作者：
Wierusz-Wysocka, Bogna
影响因子：
39.3
作者：
Bassan, R;Potsch, A;Moutinho, MA
通讯作者：
Moutinho, MA
影响因子：
37.8
作者：
Pearson, TA;Mensah, GA;Vinicor, F
通讯作者：
Vinicor, F
影响因子：
4.9
作者：
Floris-Moore, Michelle;Howard, Andrea A.;Klein, Robert S.
通讯作者：
Klein, Robert S.
影响因子：
6
作者：
Matsumori, A;Shimada, T;Mason, JW
通讯作者：
Mason, JW