Modifying effect of calcium/magnesium intake ratio and mortality: a population-based cohort study.
Modifying effect of calcium/magnesium intake ratio and mortality: a population-based cohort study.
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DOI：
10.1136/bmjopen-2012-002111
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发表时间：
2013
期刊：
影响因子：
2.9
通讯作者：
Zheng W
中科院分区：
文献类型：
--
作者：
Dai Q;Shu XO;Deng X;Xiang YB;Li H;Yang G;Shrubsole MJ;Ji B;Cai H;Chow WH;Gao YT;Zheng W
镁（Mg）和钙（Ca）在（再）吸收、炎症和许多其他生理活动中相互拮抗。根据数学估计，钙或镁的吸收量取决于膳食钙镁摄入量的比例。我们假设饮食中的钙/镁比例改变了钙和镁对胃肠道癌死亡率的影响，也许还改变了其他器官或系统疾病的死亡率。前瞻性研究。在中国上海进行的基于人群的队列研究（上海女性健康研究和上海男性健康研究）。74942名40-70岁的中国女性和61500名40-74岁的中国男性参与了这项研究。 全因死亡率和疾病特异性死亡率。在钙/镁摄入比例较低的中国人群中（中位数为1.7，美国人群约为3.0），镁摄入量高于美国推荐每日摄入量（RDA）水平（女性为320 mg/天，男性为420 mg/天）与女性和男性总死亡率风险增加相关。 与我们的假设一致，钙/镁摄入量的比例显着修改的钙和镁的摄入量与死亡风险的关联，而没有显着的相互作用之间的钙和镁的结果被发现。在Ca/Mg比值>1.7的男性中，Ca和Mg摄入量的增加与总死亡率和冠心病死亡率的风险降低有关。在同一组中，钙的摄入量与癌症死亡率的降低有关。在钙镁比≤1.7的女性中，镁的摄入量与总死亡率、心血管疾病和结直肠癌死亡率的风险增加相关。这些结果，如果得到证实，可能有助于了解钙和镁之间的最佳平衡的病因和预防这些常见疾病和降低死亡率。
Magnesium (Mg) and calcium (Ca) antagonise each other in (re)absorption, inflammation and many other physiological activities. Based on mathematical estimation, the absorbed number of Ca or Mg depends on the dietary ratio of Ca to Mg intake. We hypothesise that the dietary Ca/Mg ratio modifies the effects of Ca and Mg on mortality due to gastrointestinal tract cancer and, perhaps, mortality due to diseases occurring in other organs or systems. Prospective studies. Population-based cohort studies (The Shanghai Women's Health Study and the Shanghai Men's Health Study) conducted in Shanghai, China. 74 942 Chinese women aged 40–70 years and 61 500 Chinese men aged 40–74 years participated in the study. All-cause mortality and disease-specific mortality. In this Chinese population with a low Ca/Mg intake ratio (a median of 1.7 vs around 3.0 in US populations), intakes of Mg greater than US Recommended Daily Allowance (RDA) levels (320 mg/day among women and 420 mg/day among men) were related to increased risks of total mortality for both women and men. Consistent with our hypothesis, the Ca/Mg intake ratio significantly modified the associations of intakes of Ca and Mg with mortality risk, whereas no significant interactions between Ca and Mg in relation to outcome were found. The associations differed by gender. Among men with a Ca/Mg ratio >1.7, increased intakes of Ca and Mg were associated with reduced risks of total mortality, and mortality due to coronary heart diseases. In the same group, intake of Ca was associated with a reduced risk of mortality due to cancer. Among women with a Ca/Mg ratio ≤1.7, intake of Mg was associated with increased risks of total mortality, and mortality due to cardiovascular diseases and colorectal cancer. These results, if confirmed, may help to understand the optimal balance between Ca and Mg in the aetiology and prevention of these common diseases and reduction in mortality.
影响因子：
2.9
作者：
Dai Q;Shu XO;Deng X;Xiang YB;Li H;Yang G;Shrubsole MJ;Ji B;Cai H;Chow WH;Gao YT;Zheng W
通讯作者：
Zheng W