Glial and neuroinflammatory targets for treating substance use disorders.
Glial and neuroinflammatory targets for treating substance use disorders.
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DOI：
10.1016/j.drugalcdep.2017.08.003
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发表时间：
2017-11-01
影响因子：
4.2
通讯作者：
Comer SD
中科院分区：
文献类型：
--
作者：
Bachtell RK;Jones JD;Heinzerling KG;Beardsley PM;Comer SD
2016年行为，生物学和化学：成瘾转化研究会议的全体会议重点关注神经胶质细胞在物质使用障碍的发展，持续性和治疗中的潜在作用。胶质细胞参与各种功能，这些功能对健康的大脑活动很重要。滥用药物改变神经胶质细胞的活性，使大脑功能产生几种扰动，这些扰动被认为有助于与物质使用障碍相关的行为变化。因此，药物诱导的变化，神经胶质细胞驱动的过程中，在大脑中的药物治疗药物治疗物质使用障碍的潜在目标。四位发言者介绍了临床前和临床研究，说明了神经胶质调节剂对精神兴奋剂和类阿片滥用相关行为影响的影响。这篇综述强调了其中的一些发现，并将其重点扩大到其他研究，重点是药物诱导的神经胶质异常和以神经胶质为中心的治疗方法在物质使用障碍。临床前研究结果表明，滥用药物通过与小胶质细胞和星形胶质细胞的相互作用诱导神经炎症信号并破坏谷氨酸稳态。测试神经胶质调节剂的作用的临床前和临床研究显示了减少与物质使用障碍相关的行为的一般有效性。药物诱导的神经胶质细胞活性的贡献继续成为药物使用障碍治疗的一个有趣的目标。神经胶质调节剂的临床研究已经在物质使用措施方面取得了令人鼓舞的结果，并表明它们通常是安全和耐受性良好的。然而，结果并不完全是积极的，在开发和测试胶质定向治疗药物使用障碍方面仍有更多的问题需要继续探索。
The plenary session at the 2016 Behavior, Biology and Chemistry: Translational Research in Addiction Conference focused on glia as potential players in the development, persistence and treatment of substance use disorders. Glia partake in various functions that are important for healthy brain activity. Drugs of abuse alter glial cell activity producing several perturbations in brain function that are thought to contribute to behavioral changes associated with substance use disorders. Consequently, drug-induced changes in glia-driven processes in the brain represent potential targets for pharmacotherapeutics treating substance use disorders. Four speakers presented preclinical and clinical research illustrating the effects that glial modulators have on abuse-related behavioral effects of psychostimulants and opioids. This review highlights some of these findings and expands its focus to include other research focused on drug-induced glia abnormalities and glia-focused treatment approaches in substance use disorders. Preclinical findings show that drugs of abuse induce neuroinflammatory signals and disrupt glutamate homeostasis through their interaction with microglia and astrocytes. Preclinical and clinical studies testing the effects of glial modulators show general effectiveness in reducing behaviors associated with substance use disorders. The contribution of drug-induced glial activity continues to emerge as an intriguing target for substance use disorder treatments. Clinical investigations of glial modulators have yielded promising results on substance use measures and indicate that they are generally safe and well-tolerated. However, results have not been entirely positive and more questions remain for continued exploration in the development and testing of glial-directed treatments for substance use disorders.
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影响因子：
4.2
作者：
Aal-Aaboda, Munaf;Alhaddad, Hasan;Osowik, Francis;Nauli, Surya M.;Sari, Youssef
通讯作者：
Sari, Youssef
影响因子：
5.3
作者：
Ben Haim L;Carrillo-de Sauvage MA;Ceyzériat K;Escartin C
通讯作者：
Escartin C
DOI：
10.1196/annals.1300.023
发表时间：
2003-01-01
期刊：
GLUTAMATE AND DISORDERS OF COGNITION AND MOTIVATION
影响因子：
--
作者：
Baker, DA;McFarland, K;Kalivas, PW
通讯作者：
Kalivas, PW
影响因子：
5.3
作者：
Alfonso-Loeches, Silvia;Pascual-Lucas, Maya;Guerri, Consuelo
通讯作者：
Guerri, Consuelo
DOI：
10.1016/b978-0-12-420118-7.00001-9
发表时间：
2014
期刊：
Advances in pharmacology (San Diego, Calif.)
影响因子：
--
作者：
Beardsley, Patrick M;Hauser, Kurt F
通讯作者：
Hauser, Kurt F