S1P control of endothelial integrity.
S1P control of endothelial integrity.
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DOI：
10.1007/978-3-319-05879-5_4
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发表时间：
2014
影响因子：
--
通讯作者：
Hla, Timothy
中科院分区：
文献类型：
--
作者：
Xiong, Yuquan;Hla, Timothy
Sphingosine 1-phosphate (S1P), a lipid mediator produced by sphingolipid metabolism, promotes endothelial cell spreading, vascular maturation/stabilization, and barrier function. S1P is present at high concentrations in the circulatory system, whereas in tissues its levels are low. This so-called vascular S1P gradient is essential for S1P to regulate much physiological and pathophysiological progress such as the modulation of vascular permeability. Cellular sources of S1P in blood has only recently begun to be identified. In this review, we summarize the current understanding of S1P in regulating vascular integrity. In particular, we discuss the recent discovery of the endothelium-protective functions of HDL-bound S1P which is chaperoned by apolipoprotein M.
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影响因子：
4.5
作者：
Argraves KM;Sethi AA;Gazzolo PJ;Wilkerson BA;Remaley AT;Tybjaerg-Hansen A;Nordestgaard BG;Yeatts SD;Nicholas KS;Barth JL;Argraves WS
通讯作者：
Argraves WS
影响因子：
4.8
作者：
Dudek, S. M.;Camp, S. M.;Singleton, P. A.
通讯作者：
Singleton, P. A.
影响因子：
4
作者：
Bode, Constantin;Sensken, Sven-Christian;Graeler, Markus H.
通讯作者：
Graeler, Markus H.
影响因子：
6.5
作者：
Christoffersen, Christina;Nielsen, Lars Bo;Dahlback, Bjorn
通讯作者：
Dahlback, Bjorn
FAK在S1P调节的内皮通透性中的作用。
影响因子：
3.1
作者：
Belvitch P;Dudek SM
通讯作者：
Dudek SM