Intrafollicular fibroblast growth factor 13 in polycystic ovary syndrome: relationship with androgen levels and oocyte developmental competence.
Intrafollicular fibroblast growth factor 13 in polycystic ovary syndrome: relationship with androgen levels and oocyte developmental competence.
复制标题
多囊卵巢综合征中的卵泡内成纤维细胞生长因子 13：与雄激素水平和卵母细胞发育能力的关系
DOI：
10.1186/s13048-018-0455-3
复制
发表时间：
2018-09-26
影响因子：
4
通讯作者：
Liu W
中科院分区：
文献类型：
--
作者：
Liu Y;Li S;Tao T;Li X;Zhu Q;Liao Y;Ma J;Sun Y;Liu W
背景成纤维细胞生长因子 13 (FGF13) 是成年小鼠卵巢中表达最高的 FGF 家族成员之一。然而，其在卵巢功能中的确切作用仍然很大程度上未知。我们试图评估多囊卵巢综合征 (PCOS) 患者卵泡液中的 FGF13 与卵母细胞发育能力之间的关系。方法对 43 名 PCOS 患者和 32 名接受体外受精/胞浆内单精子注射治疗的非 PCOS 患者进行横断面研究。卵泡液 (FF)-FGF13 (≥117.51 pg/mL) 和 FF-总睾酮 (FF-TT) (≥51.90 nmol/L) 的最高四分位数分别定义为“升高的”FF-FGF13 水平和“升高的”FF-TT 水平。结果 FF-FGF13 的水平存在偏差，中位数 75 名患者中的浓度为 82.97 pg/mL (59.79–117.51 pg/mL)。 FF-FGF13 水平升高的 PCOS 患者中 FF-TT 水平升高的患病率显着高于 FF-FGF13 水平不升高的 PCOS 患者（64.3% vs. 35.7%，调整后 P= 0.0096）。 PCOS 患者中 FF-TT 和卵巢体积增大（一侧或双侧卵巢 > 10 mL）与 FF-FGF13 呈正相关（r= 0.37，P= 0.013；r= 0.33，P= 0.032）。多元线性回归分析显示FF-FGF13与MII卵母细胞率呈明显负相关（β = − 0.10，SE = 0.045，调整P= 0.027）。然而，这种关联在非PCOS患者中并不明显。结论我们的研究表明PCOS患者滤泡内存在FGF13，并暗示FGF13可能参与PCOS的病理生理过程。
BackgroundFibroblast growth factor 13 (FGF13) is one of the most highly expressed FGF family members in adult mouse ovary. However, its precise roles in ovarian function remain largely unknown. We sought to evaluate the associations between FGF13 in follicular fluid and oocyte developmental competence in patients with polycystic ovary syndrome (PCOS).MethodsA cross-sectional study was conducted on 43 patients with PCOS and 32 non-PCOS patients who underwent in vitro fertilization/intracytoplasmic sperm injection treatments. The highest quartiles of follicular fluid (FF)-FGF13 (≥117.51 pg/mL) and FF-total testosterone (FF-TT) (≥51.90 nmol/L) were defined as “elevated” FF-FGF13 levels and “elevated” FF-TT levels, respectively.ResultsThe levels of FF-FGF13 were skewed, with a median of 82.97 pg/mL (59.79–117.51 pg/mL) in 75 patients. The prevalence of elevated FF-TT levels was significantly higher in the PCOS patients with elevated FF-FGF13 levels than in those without (64.3% vs. 35.7%, adjustedP= 0.0096). FF-TT and increased ovarian volume (> 10 mL for one or both ovaries) were positively correlated with FF-FGF13 in PCOS patients (r= 0.37,P= 0.013;r= 0.33,P= 0.032). A negative association was evident between FF-FGF13 and the MII oocyte rate in the multiple linear regression analysis (β = − 0.10, SE = 0.045, adjustedP= 0.027). However, the associations were not evident in the non-PCOS patients.ConclusionsOur study suggests the presence of intrafollicular FGF13 in PCOS patients and implies that FGF13 might be involved in the pathophysiological process of PCOS.
登录
查看更多内容
影响因子：
6.1
作者：
Chen, Yu-Ching;Chang, Hsun-Ming;Leung, Peter C. K.
通讯作者：
Leung, Peter C. K.
影响因子：
3.7
作者：
LAVRANOS, TC;RODGERS, HF;RODGERS, RJ
通讯作者：
RODGERS, RJ
影响因子：
3.3
作者：
VERNON, RK;SPICER, LJ
通讯作者：
SPICER, LJ
影响因子：
9.2
作者：
Schoorlemmer, J;Goldfarb, M
通讯作者：
Goldfarb, M
影响因子：
6.7
作者：
Chang, J;Azziz, R;Lobo, R
通讯作者：
Lobo, R