Bacteroides in the infant gut consume milk oligosaccharides via mucus-utilization pathways.
Bacteroides in the infant gut consume milk oligosaccharides via mucus-utilization pathways.
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DOI：
10.1016/j.chom.2011.10.007
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发表时间：
2011-11-17
影响因子：
30.3
通讯作者：
Sonnenburg JL
中科院分区：
文献类型：
--
作者：
Marcobal A;Barboza M;Sonnenburg ED;Pudlo N;Martens EC;Desai P;Lebrilla CB;Weimer BC;Mills DA;German JB;Sonnenburg JL
新生儿在出生后不久就被肠道微生物群定殖，但控制特定微生物谱系的保留和丰度的因素尚不清楚。哺乳期婴儿食用人乳低聚糖（HMO），这些低聚糖未经消化进入远端肠道，在那里它们可能被微生物消化。我们确定，主要的新生儿肠道居民多形拟杆菌和脆弱拟杆菌在HMO消耗期间诱导用于收获宿主粘液聚糖的相同基因，所述粘液聚糖在结构上与HMO相似。乳糖-N-新四糖是一种特定的HMO组分，选择HMO适应性物种，如不能使用粘液的双歧杆菌，并为B提供选择优势。当与B双缔合时，在体内抑制。在gnotobiotic小鼠肠道中的多形核。这表明HMO中的复杂寡糖混合物将互惠粘液适应性物种和HMO适应性双歧杆菌吸引到婴儿肠道，这可能促进牛奶和未来固体食物的消化。
Newborns are colonized with an intestinal microbiota shortly after birth but the factors governing the retention and abundance of specific microbial lineages are unknown. Nursing infants consume human milk oligosaccharides (HMOs) that pass undigested to the distal gut where they may be digested by microbes. We determined that the prominent neonate gut residents, Bacteroides thetaiotaomicron and Bacteroides fragilis, induce the same genes during HMO consumption that are used to harvest host mucus glycans, which are structurally similar to HMOs. Lacto-N-neotetraose, a specific HMO component, selects for HMO-adapted species such as Bifidobacterium infantis, which cannot use mucus, and provides a selective advantage to B. infantis in vivo when bi-associated with B. thetaiotaomicron in the gnotobiotic mouse gut. This indicates that the complex oligosaccharide mixture within HMOs attracts both mutualistic mucus-adapted species and HMO-adapted bifidobacteria to the infant intestine that likely facilitate both milk and future solid food digestion.
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影响因子：
30.3
作者：
Martens EC;Chiang HC;Gordon JI
通讯作者：
Gordon JI
影响因子：
64.5
作者：
Sonnenburg ED;Zheng H;Joglekar P;Higginbottom SK;Firbank SJ;Bolam DN;Sonnenburg JL
通讯作者：
Sonnenburg JL
影响因子：
4.1
作者：
Robbe, C;Capon, C;Michalski, JC
通讯作者：
Michalski, JC
影响因子：
6.1
作者：
Locascio, Riccardo G.;Ninonuevo, Milady R.;German, J. Bruce
通讯作者：
German, J. Bruce
影响因子：
3.2
作者：
Brigham, Christopher;Caughlan, Ruth;Malamy, Michael H.
通讯作者：
Malamy, Michael H.