Genetics of Healthy Aging in Europe
Genetics of Healthy Aging in Europe
复制标题
欧洲健康老龄化的遗传学
DOI：
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发表时间：
2007
影响因子：
5.2
通讯作者：
J. Vaupel
中科院分区：
文献类型：
--
作者：
C. Franceschi;V. Bezrukov;H. Blanché;L. Bolund;K. Christensen;G. Benedictis;L. Deiana;E. Gonos;A. Hervonen;Huanning Yang;B. Jeune;T. Kirkwood;P. Kristensen;A. Leon;P. Pelicci;L. Peltonen;M. Poulain;I. Rea;J. Remacle;J. Robine;S. Schreiber;E. Sikora;P. Slagboom;L. Spazzafumo;M. Stazi;O. Toussaint;J. Vaupel
摘要： 由25个合作伙伴(欧洲24个，北京中国基因组研究所)组成的为期5年的欧盟-健康老龄化遗传学综合项目的目的是识别与健康衰老和长寿相关的基因，使个人能够在良好的认知和身体功能以及没有重大年龄相关疾病的情况下存活到高龄。为了实现这一目标，已经建立了一个连贯的、紧密整合的研究计划，将人口学家、老年病学家、遗传学家、遗传流行病学家、分子生物学家、生物信息学家和统计学家联合起来。工作计划是：(A)从来自11个欧洲国家的空前数量的长寿90岁以上同胞对(n=2650)和较年轻的种族匹配对照(n=2650)中收集DNA和关于健康状况的信息；(B)对所有同胞对(总共5300人)进行全基因组连锁扫描；这项调查之后将对候选染色体区域进行连锁不平衡图谱绘制；(C)对病例(即，兄弟姐妹的2650名先证者)和对照组(2650名年轻人)进行研究，以前的研究确定的基因组区域(4号染色体，D4S1564，11号染色体，11.p15.5)可能含有长寿基因；(D)对所有招募的受试者进行apoE基因多态研究；(E)对所有招募的线粒体DNA(MtDNA)遗传和表观遗传变异性的受试者进行研究。基因分析将由9个高通量平台在表型、遗传和线粒体DNA数据的中央数据库框架内进行。设想了更多的先进方法(生物信息学、高级统计学、数学建模、功能基因组学和蛋白质组学、分子生物学、分子遗传学)来识别感兴趣的基因变体(S)。实验设计还将允许(A)确定与男女健康老龄化和长寿有关的性别特定基因，按种族和地理来源以及载脂蛋白E基因型分层；(B)进行纵向生存研究，以评估已确定的基因座对90多人死亡率的影响；(C)开发能够将遗传数据与人口统计特征、健康状况、社会经济因素和生活习惯相结合的数学和统计模型。
Abstract: The aim of the 5‐year European Union (EU)‐Integrated Project GEnetics of Healthy Aging (GEHA), constituted by 25 partners (24 from Europe plus the Beijing Genomics Institute from China), is to identify genes involved in healthy aging and longevity, which allow individuals to survive to advanced old age in good cognitive and physical function and in the absence of major age‐related diseases. To achieve this aim a coherent, tightly integrated program of research that unites demographers, geriatricians, geneticists, genetic epidemiologists, molecular biologists, bioinfomaticians, and statisticians has been set up. The working plan is to: (a) collect DNA and information on the health status from an unprecedented number of long‐lived 90+ sibpairs (n= 2650) and of younger ethnically matched controls (n= 2650) from 11 European countries; (b) perform a genome‐wide linkage scannning in all the sibpairs (a total of 5300 individuals); this investigation will be followed by linkage disequilibrium mapping (LD mapping) of the candidate chromosomal regions; (c) study in cases (i.e., the 2650 probands of the sibpairs) and controls (2650 younger people), genomic regions (chromosome 4, D4S1564, chromosome 11, 11.p15.5) which were identified in previous studies as possible candidates to harbor longevity genes; (d) genotype all recruited subjects for apoE polymorphisms; and (e) genotype all recruited subjects for inherited as well as epigenetic variability of the mitochondrial DNA (mtDNA). The genetic analysis will be performed by 9 high‐throughput platforms, within the framework of centralized databases for phenotypic, genetic, and mtDNA data. Additional advanced approaches (bioinformatics, advanced statistics, mathematical modeling, functional genomics and proteomics, molecular biology, molecular genetics) are envisaged to identify the gene variant(s) of interest. The experimental design will also allow (a) to identify gender‐specific genes involved in healthy aging and longevity in women and men stratified for ethnic and geographic origin and apoE genotype; (b) to perform a longitudinal survival study to assess the impact of the identified genetic loci on 90+ people mortality; and (c) to develop mathematical and statistical models capable of combining genetic data with demographic characteristics, health status, socioeconomic factors, lifestyle habits.
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遗传对生物衰老的贡献：弗雷明汉研究。
DOI：
10.1093/gerona/59.3.b218
发表时间：
2004
期刊：
The journals of gerontology. Series A, Biological sciences and medical sciences
影响因子：
--
作者：
Karasik,David;Hannan,MarianT;Cupples,LAdrienne;Felson,DavidT;Kiel,DouglasP
通讯作者：
Kiel,DouglasP
影响因子：
120.7
作者：
Barzilai, N;Atzmon, G;Shuldiner, AR
通讯作者：
Shuldiner, AR
单倍型对人类生存的影响：应用于非定相基因型数据的逻辑回归模型。
DOI：
10.1046/j.1529-8817.2004.00143.x
发表时间：
2005
期刊：
Annals of human genetics.
影响因子：
--
作者：
Tan,Q;Christiansen,L;Bathum,L;Zhao,JH;Vach,W;Vaupel,JW;Christensen,K;Kruse,TA
通讯作者：
Kruse,TA
基因与长寿：百岁老人研究的教训。
DOI：
10.1093/gerona/55.7.b319
发表时间：
2000
期刊：
The journals of gerontology. Series A, Biological sciences and medical sciences
影响因子：
--
作者：
Yashin,AI;DeBenedictis,G;Vaupel,JW;Tan,Q;Andreev,KF;Iachine,IA;Bonafe,M;Valensin,S;DeLuca,M;Carotenuto,L;Franceschi,C
通讯作者：
Franceschi,C