Quality control mechanisms that protect nuclear envelope identity and function.
Quality control mechanisms that protect nuclear envelope identity and function.
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DOI：
10.1083/jcb.202205123
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发表时间：
2022-09-05
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核膜包围并保护基因组。Mannino和Lusk探索了一套独特的质量控制途径，以保持其身份和功能。核被膜（NE）是内质网的特化，具有独特的生物化学，其限定在容纳核孔复合物（NPC）的孔膜处连接的内膜和外膜。维持这些膜的物理完整性和生物化学特性的质量控制机制对于确保NE充当也有助于基因组稳定性和代谢的选择性屏障至关重要。由于NE的蛋白质组是高度整合的，因此通过传统的泛素-蛋白酶体和自噬机制进行翻转是具有挑战性的。此外，去除NE的整个部分需要复杂的膜重塑，这是知之甚少。尽管如此，最近的工作已经取得了进展，发现专门的细胞降解机制，以满足由NE施加的独特挑战。此外，细胞已经进化出监测和修复NE屏障的机制，以防止NE完整性破坏的有害影响，其形式为破裂的NE或功能障碍的NPC。在这里，我们综合了最新的工作，探索NE质量控制机制在真核生物。
The nuclear envelope surrounds and protects the genome. Mannino and Lusk explore the unique set of quality control pathways that maintain its identity and function. The nuclear envelope (NE) is a specialization of the endoplasmic reticulum with distinct biochemistry that defines inner and outer membranes connected at a pore membrane that houses nuclear pore complexes (NPCs). Quality control mechanisms that maintain the physical integrity and biochemical identity of these membranes are critical to ensure that the NE acts as a selective barrier that also contributes to genome stability and metabolism. As the proteome of the NE is highly integrated, it is challenging to turn over by conventional ubiquitin-proteasome and autophagy mechanisms. Further, removal of entire sections of the NE requires elaborate membrane remodeling that is poorly understood. Nonetheless, recent work has made inroads into discovering specializations of cellular degradative machineries tailored to meeting the unique challenges imposed by the NE. In addition, cells have evolved mechanisms to surveil and repair the NE barrier to protect against the deleterious effects of a breach in NE integrity, in the form of either a ruptured NE or a dysfunctional NPC. Here, we synthesize the most recent work exploring NE quality control mechanisms across eukaryotes.
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影响因子：
3.3
作者：
Borah S;Thaller DJ;Hakhverdyan Z;Rodriguez EC;Isenhour AW;Rout MP;King MC;Lusk CP
通讯作者：
Lusk CP
影响因子：
7.5
作者：
Day KJ;Stachowiak JC
通讯作者：
Stachowiak JC
影响因子：
8.8
作者：
Christiano R;Nagaraj N;Fröhlich F;Walther TC
通讯作者：
Walther TC
DOI：
10.1073/pnas.1716305114
发表时间：
2017-12-26
影响因子：
11.1
作者：
Albert S;Schaffer M;Beck F;Mosalaganti S;Asano S;Thomas HF;Plitzko JM;Beck M;Baumeister W;Engel BD
通讯作者：
Engel BD
影响因子：
17.1
作者：
通讯作者：
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