Central nervous system neuroplasticity and the sensitization of hypertension.
Central nervous system neuroplasticity and the sensitization of hypertension.
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DOI：
10.1038/s41581-018-0068-5
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发表时间：
2018-12
期刊：
影响因子：
--
通讯作者：
Xue B
中科院分区：
文献类型：
--
作者：
Johnson AK;Xue B
高血压的病因仍然是个谜。遗传因素和外部因素之间的相互作用通常被认为是触发高血压发病的病因学机制。然而，什么基因和因素参与，以及这种相互作用发生在何时何地，这些问题仍然没有解决。新出现的证据表明，高血压对升压刺激的反应，就像许多其他的生理和行为适应一样，可以对特定的刺激敏感。动物模型的研究表明，与大脑控制的其他反应系统类似，高血压反应敏化(HTRS)是由神经可塑性介导的。HTRS涉及的大脑回路控制着交感神经系统。这篇综述概述了支持HTRS现象的证据，并描述了可导致敏感型高血压状态的生理和心理社会应激源的范围。还讨论了控制交感神经张力的大脑神经网络中细胞和分子的变化，这些神经网络参与了与应激源相关的信息的长期存储，这可能有助于维持敏感状态。最后，这篇综述最后讨论了为什么敏化的高血压反应在以前可能是有益的，并在某些环境条件下增加了生物适合性，以及为什么今天它已经成为一种与健康相关的负担。
The causes of essential hypertension remain an enigma. Interactions between genetic and external factors are generally recognized to act as aetiological mechanisms that trigger the pathogenesis of high blood pressure. However, the questions of what genes and factors are involved, and when and where such interactions occur, remain unresolved. Emerging evidence indicates that the hypertensive response to pressor stimuli, like many other physiological and behavioural adaptations, can become sensitized to particular stimuli. Studies in animal models show that, similarly to other response systems controlled by the brain, hypertensive response sensitization (HTRS) is mediated by neuroplasticity. The brain circuitry involved in HTRS controls the sympathetic nervous system. This Review outlines evidence supporting the phenomena of HTRS and describes the range of physiological and psychosocial stressors that can produce a sensitized hypertensive state. Also discussed are the cellular and molecular changes in the brain neural network controlling sympathetic tone involved in long-term storage of information relating to stressors, which could serve to maintain a sensitized state. Finally, this Review concludes with a discussion of why a sensitized hypertensive response might previously have been beneficial and increased biological fitness under some environmental conditions, and why today it has become a health-related liability.
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影响因子：
5.3
作者：
Barnett, William H.;Abdala, Ana P.;Paton, Julian F. R.;Rybak, Ilya A.;Zoccal, Daniel B.;Molkov, Yaroslav I.
通讯作者：
Molkov, Yaroslav I.
影响因子：
5.5
作者：
BLISS, TVP;LOMO, T
通讯作者：
LOMO, T
影响因子：
5.5
作者：
ABRAHAMS, VC;HILTON, SM;ZBROZYNA, A
通讯作者：
ZBROZYNA, A
影响因子：
8.3
作者：
Alexander, BT;Hendon, AE;Dwyer, TM
通讯作者：
Dwyer, TM
影响因子：
--
作者：
BLAIR, ML;FEIGL, EO;SMITH, OA
通讯作者：
SMITH, OA