The virologic and immunologic effects of cyclosporine as an adjunct to antiretroviral therapy in patients treated during acute and early HIV-1 infection.
The virologic and immunologic effects of cyclosporine as an adjunct to antiretroviral therapy in patients treated during acute and early HIV-1 infection.
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DOI：
10.1086/651664
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发表时间：
2010-05-01
期刊：
影响因子：
--
通讯作者：
Little S
中科院分区：
文献类型：
--
作者：
Markowitz M;Vaida F;Hare CB;Boden D;Mohri H;Hecht FM;Kalayjian RC;Conrad A;Mildvan D;Aberg J;Hogan C;Kilby JM;Balfour HH Jr;Schafer K;Richman D;Little S
急性HIV-1感染的特征是高水平的免疫激活。在急性和早期HIV-1感染的情况下，环孢菌素A联合抗逆转录病毒治疗（ART）的免疫调节已被报道可增强免疫重建。54例急性和早期感染患者随机接受ART联合4周环孢素A治疗，与单独接受ART治疗相比。在完成研究的48例受试者中，治疗组之间的前病毒DNA水平或CD 4 + T细胞计数无显著差异。在这种情况下，环孢霉素A辅助治疗不能提供明显的病毒学或免疫学获益。
Acute HIV-1 infection is characterized by high levels of immune activation. Immunomodulation with Cyclosporin A combined with antiretroviral therapy (ART) in the setting of acute and early HIV-1 infection has been reported to result in enhanced immune reconstitution. Fifty-four individuals with acute and early infection were randomized to receive ART with 4 weeks of Cyclosporine A versus ART alone. In 48 subjects who completed the study, there were no significant differences between treatment arms in levels of proviral DNA or CD4+ T cell counts. Adjunctive therapy with Cyclosporine A in this setting does not provide apparent virologic or immunologic benefit.
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DOI：
10.1073/pnas.97.7.3382
发表时间：
2000-03-28
影响因子：
11.1
作者：
Oxenius, A;Price, DA;Phillips, RE
通讯作者：
Phillips, RE
影响因子：
39.2
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Schacker, TW;Hughes, JP;Corey, L
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Corey, L
影响因子：
15.9
作者：
Rizzardi, GP;Harari, A;Pantaleo, G
通讯作者：
Pantaleo, G
DOI：
10.1084/jem.20041196
发表时间：
2004-09-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Mehandru S;Poles MA;Tenner-Racz K;Horowitz A;Hurley A;Hogan C;Boden D;Racz P;Markowitz M
通讯作者：
Markowitz M
DOI：
10.1097/qai.0b013e31817ecb31
发表时间：
2008-08-15
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Mohri H;Markowitz M
通讯作者：
Markowitz M