Case report: Successful treatment of non-bullous lichen planus pemphigoides with dupilumab.
Case report: Successful treatment of non-bullous lichen planus pemphigoides with dupilumab.
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DOI：
10.3389/fmed.2022.1023458
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发表时间：
2022
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
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作者：
扁平苔藓(LPP)是一种罕见的自身免疫性大疱病，以扁平苔藓和真皮下大疱病共存为特征。然而，少数LPP患者出现丘疹，而不是水泡或水泡，这被定义为非大疱性LPP。LPP的诊断依赖于临床表现、组织病理学、血清学检测和直接免疫荧光法，即免疫球蛋白G和/或补体C3在基底膜区域呈线状分布。到目前为止，对于LPP的治疗还没有提出标准的治疗策略。在此，我们描述了一例罕见的非大疱性LPP患者，可能由接种疫苗引起，伴有广泛的丘疹和红斑。在住院期间，他对常规的局部和全身皮质类固醇治疗反应不佳，最终通过添加杜匹鲁单抗缓解了他的病情。对于传统药物治疗失败的LPP患者，或者不适合使用大剂量皮质类固醇的患者，联合使用dupilumab可能是一种替代选择。
Lichen planus pemphigoides (LPP) is a rare autoimmune bullous disease, characterized by the coexistence of lichen planus and subepidermal bullae. However, the minority of LPP patients present with papules rather than vesicles or blisters, which is defined as non-bullous LPP. The diagnosis of LPP relies on manifestations, histopathology, serological assay, and direct immunofluorescence of linear disposition of IgG and/or C3 at the basement membrane zone. Up to now, no standard therapeutic strategies have been proposed for the treatment of LPP. Herein, we describe an uncommon non-bullous LPP patient with widespread papules and erythema, probably induced by vaccination. During hospitalization, he had a poor response to the conventional treatment of topical and systemic corticosteroids, and his condition was finally alleviated by the addition of dupilumab. For LPP patients with a traditional medication failure, or who were not suitable for a higher dose of corticosteroids, a combination with dupilumab could be an alternative option.
影响因子：
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作者：
Lahouel, M;Aounallah, A;Mokni, S;Sriha, B;Belajouza, C;Denguezli, M
通讯作者：
Denguezli, M