Spatial TIME landscape and its prognostic value in the lung and brain tumor: location matters.
Spatial TIME landscape and its prognostic value in the lung and brain tumor: location matters.
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DOI：
10.1038/s41392-023-01473-w
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发表时间：
2023-05-08
影响因子：
39.3
通讯作者：
Yan, Jun
中科院分区：
文献类型：
--
作者：
Wang, Yunke;Geller, Anne E.;Yan, Jun
在《自然》杂志最近发表的两篇论文中，1，2 Logan沃尔什及其同事利用成像质量细胞术（IMC）在416名肺腺癌（LUAD）患者的肺肿瘤以及139名高级别胶质瘤和46名脑转移（BrM）患者的脑肿瘤中创建了肿瘤免疫微环境（TIME）的全面单细胞空间景观。通过进行彻底的分析来表征细胞空间相互作用和邻域模式，并将这些空间特征与临床结果相关联（图1），研究人员获得了对肿瘤结构复杂性的新见解。最终，他们确定了两组临床相关的预测性免疫标志物，可用于帮助指导临床决策。
In two recently published papers in Nature, 1, 2 Logan Walsh and colleagues utilized imaging mass cytometry (IMC) to create comprehensive single-cell spatial landscapes of the tumor immune microenvironment (TIME) in lung tumors from 416 lung adenocarcinoma (LUAD) patients, as well as brain tumors from 139 high-grade glioma and 46 brain metastasis (BrM) patients. By conducting a thorough analysis to characterize cellular spatial interactions and neighborhood patterns, and correlating these spatial features with clinical outcomes (Fig. 1), the researchers gained novel insights into the complexities of tumoral architecture. Ultimately, they identified two sets of clinically relevant predictive immune markers that could be used to assist in guiding clinical decisions.
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影响因子：
64.8
作者：
Sorin, Mark;Rezanejad, Morteza;Karimi, Elham;Fiset, Benoit;Desharnais, Lysanne;Perus, Lucas J. M.;Milette, Simon;Yu, Miranda W. W.;Maritan, Sarah M. M.;Dore, Samuel;Pichette, Emilie;Enlow, William;Gagne, Andreanne;Wei, Yuhong;Orain, Michele;Manem, Venkata S. K.;Rayes, Roni;Siegel, Peter M. M.;Camilleri-Broet, Sophie;Fiset, Pierre Olivier;Desmeules, Patrice;Spicer, Jonathan D. D.;Quail, Daniela F. F.;Joubert, Philippe;Walsh, Logan A. A.
通讯作者：
Walsh, Logan A. A.
影响因子：
24.8
作者：
Moldoveanu, Dan;Ramsay, LeeAnn;Watson, Ian R.
通讯作者：
Watson, Ian R.
影响因子：
64.8
作者：
Karimi, Elham;Yu, Miranda W. W.;Maritan, Sarah M.;Perus, Lucas J. M.;Rezanejad, Morteza;Sorin, Mark;Dankner, Matthew;Fallah, Parvaneh;Dore, Samuel;Zuo, Dongmei;Fiset, Benoit;Kloosterman, Daan J.;Ramsay, LeeAnn;Wei, Yuhong;Lam, Stephanie;Alsajjan, Roa;Watson, Ian R.;Roldan Urgoiti, Gloria;Park, Morag;Brandsma, Dieta;Senger, Donna L.;Chan, Jennifer A. A.;Akkari, Leila;Petrecca, Kevin;Guiot, Marie-Christine;Siegel, Peter M.;Quail, Daniela F.;Walsh, Logan A.
通讯作者：
Walsh, Logan A.
影响因子：
64.8
作者：
Jackson, Hartland W.;Fischer, Jana R.;Bodenmiller, Bernd
通讯作者：
Bodenmiller, Bernd