Historical comparison of perfluorooctanesulfonate, perfluorooctanoate, and other fluorochemicals in human blood.
Historical comparison of perfluorooctanesulfonate, perfluorooctanoate, and other fluorochemicals in human blood.
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DOI：
10.1289/ehp.7544
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发表时间：
2005-05
影响因子：
10.4
通讯作者：
Mandel JH
中科院分区：
文献类型：
--
作者：
Olsen GW;Huang HY;Helzlsouer KJ;Hansen KJ;Butenhoff JL;Mandel JH
本次调查的目的是确定自 1974 年以来，全氟辛烷磺酸 (PFOS)、全氟辛酸 (PFOA) 和其他五种含氟化合物的人体血液浓度是否发生变化。我们于 1974 年（血清）和 1989 年（血浆）从一项大型社区健康研究的志愿者参与者中采集了血液样本。该研究总共包括 356 个样本（每个时期 178 个）。通过高压液相色谱/串联质谱法对这些样品进行分析。 1974 年和 1989 年含氟化合物浓度中位数分别如下： PFOS，29.5 ng/mL vs. 34.7 ng/mL； PFOA，2.3 ng/mL 与 5.6 ng/mL；全氟己烷磺酸盐 (PFHS)，1.6 ng/mL vs. 2.4 ng/mL；和 N-乙基全氟辛基磺酰胺乙酸酯 (PFOSAA)，低于定量下限（LLOQ；1.6 ng/mL，对比 3.4 ng/mL）。对于 N-甲基全氟辛基磺酰胺乙酸酯 (M570)、全氟辛基磺酰胺和全氟辛基磺酰胺乙酸酯，这两年的中位血清浓度均低于 LLOQ 值（分别为 1.0、1.0 和 2.5 ng/mL）。对 58 个配对样本的统计分析表明，1989 年 PFOS、PFOSAA、PFOA、PFHS 和 M570 的血清浓度显着（p < 0.001）高于 1974 年。然后将 1989 年的数据与 2001 年从同一地区的 108 名美国红十字会成年献血者收集的血清样本的几何平均含氟化合物浓度进行比较。除 M570 外，1989 年和 2001 年样品之间的几何平均含氟化合物浓度没有统计学显着性差异 (p < 0.05)。总之，根据本研究人群，1974 年至 1989 年间，全氟辛烷磺酸和其他血清氟化物浓度有所增加。与 2001 年收集的其他区域数据相比，并未表明自 1989 年以来浓度持续增加。
The purpose of this investigation was to determine whether there has been a change in the human blood concentration of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and five other fluorochemicals since 1974. Blood samples were collected in 1974 (serum) and 1989 (plasma) from volunteer participants of a large community health study. The study included a total of 356 samples (178 from each time period). These samples were analyzed by high-pressure liquid chromatography/tandem mass spectrometry methods. The median 1974 and 1989 fluorochemical concentrations, respectively, were as follows: PFOS, 29.5 ng/mL vs. 34.7 ng/mL; PFOA, 2.3 ng/mL vs. 5.6 ng/mL; perfluorohexanesulfonate (PFHS), 1.6 ng/mL vs. 2.4 ng/mL; and N-ethyl perfluorooctanesulfonamidoacetate (PFOSAA), less than the lower limit of quantitation (LLOQ; 1.6 ng/mL, vs. 3.4 ng/mL). For N-methyl perfluorooctanesulfonamidoacetate (M570), perfluorooctanesulfonamide, and perfluorooctanesulfonamidoacetate, median serum concentrations in both years were less than the LLOQ values (1.0, 1.0, and 2.5 ng/mL, respectively). Statistical analysis of 58 paired samples indicated that serum concentrations of PFOS, PFOSAA, PFOA, PFHS, and M570 were significantly (p < 0.001) higher in 1989 than in 1974. The data from 1989 were then compared with geometric mean fluorochemical concentrations of serum samples collected in 2001 from 108 American Red Cross adult blood donors from the same region. Except for M570, there were no statistically significant (p < 0.05) geometric mean fluorochemical concentration differences between the 1989 and 2001 samples. In conclusion, based on this study population, PFOS and other serum fluorochemical concentrations have increased between 1974 and 1989. Comparison with other regional data collected in 2001 did not suggest a continued increase in concentrations since 1989.
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影响因子：
3.4
作者：
Butenhoff, JL;Gaylor, DW;Zobel, LR
通讯作者：
Zobel, LR
影响因子：
8.8
作者：
Kannan, K;Choi, JW;Giesy, JP
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影响因子：
11.4
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Hansen, KJ;Johnson, HO;Dick, LA
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Dick, LA
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3.8
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Hu, WY;Jones, PD;Giesy, JP
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Giesy, JP
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11.4
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通讯作者：
Giesy, JP