miR-155 as an Important Regulator of Multiple Sclerosis Pathogenesis. A Review.
miR-155 as an Important Regulator of Multiple Sclerosis Pathogenesis. A Review.
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DOI：
10.3390/ijms22094332
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发表时间：
2021-04-21
影响因子：
5.6
通讯作者：
Saluk-Bijak J
中科院分区：
文献类型：
--
作者：
Maciak K;Dziedzic A;Miller E;Saluk-Bijak J
多发性硬化症（MS）是一种慢性免疫介导的疾病，是年轻人残疾的主要原因。microRNA（miRNAs）参与基因表达的转录后调控。其中，miR-155是炎症的关键调节因子，并在调节MS中的自身免疫应答中起作用。miR-155通过在炎症条件下下调关键连接蛋白而参与血脑屏障（BBB）破坏。它通过促进，例如，小胶质细胞活化、星形胶质细胞极化、CD 47蛋白下调及影响关键转录因子。miR-155对神经性疼痛的发展具有巨大影响，并间接影响参与缓解疼痛超敏反应的调节性T（Treg）细胞分化。这篇综述还关注了由于疾病相关应激源、脑萎缩和促炎因子而出现的神经精神症状。最近的研究揭示了miR-155在调节焦虑、应激、海马体炎症和难治性抑郁症中的作用。抑制miR-155的表达被证明是有效的，在预防MS的病理生理过程中所涉及的。这篇综述旨在支持更好地理解miR-155失调在MS病理生理的各个方面的巨大作用，并突出了这种分子的未来前景。
Multiple sclerosis (MS) is a chronic, immune-mediated disease and the leading cause of disability among young adults. MicroRNAs (miRNAs) are involved in the post-transcriptional regulation of gene expression. Of them, miR-155 is a crucial regulator of inflammation and plays a role in modulating the autoimmune response in MS. miR-155 is involved in blood–brain barrier (BBB) disruption via down-regulation of key junctional proteins under inflammatory conditions. It drives demyelination processes by contributing to, e.g., microglial activation, polarization of astrocytes, and down-regulation of CD47 protein and affecting crucial transcription factors. miR-155 has a huge impact on the development of neuropathic pain and indirectly influences a regulatory T (Treg) cell differentiation involved in the alleviation of pain hypersensitivity. This review also focused on neuropsychiatric symptoms appearing as a result of disease-associated stressors, brain atrophy, and pro-inflammatory factors. Recent studies revealed the role of miR-155 in regulating anxiety, stress, inflammation in the hippocampus, and treatment-resistant depression. Inhibition of miR-155 expression was demonstrated to be effective in preventing processes involved in the pathophysiology of MS. This review aimed to support the better understanding the great role of miR-155 dysregulation in various aspects of MS pathophysiology and highlight future perspectives for this molecule.
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影响因子：
4.7
作者：
Choi SH;Aid S;Kim HW;Jackson SH;Bosetti F
通讯作者：
Bosetti F
影响因子：
3.7
作者：
Field J;Browning SR;Johnson LJ;Danoy P;Varney MD;Tait BD;Gandhi KS;Charlesworth JC;Heard RN;Australia and New Zealand Multiple Sclerosis Genetics Consortium;Stewart GJ;Kilpatrick TJ;Foote SJ;Bahlo M;Butzkueven H;Wiley J;Booth DR;Taylor BV;Brown MA;Rubio JP;Stankovich J
通讯作者：
Stankovich J
影响因子：
7.2
作者：
Daneman, Richard;Prat, Alexandre
通讯作者：
Prat, Alexandre
影响因子：
5.3
作者：
Brites D;Fernandes A
通讯作者：
Fernandes A
影响因子：
10.7
作者：
Chakraborty C;Sharma AR;Sharma G;Lee SS
通讯作者：
Lee SS