HIV-1 molecular diversity in Brazil unveiled by 10 years of sampling by the national genotyping network.
HIV-1 molecular diversity in Brazil unveiled by 10 years of sampling by the national genotyping network.
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DOI：
10.1038/s41598-021-94542-5
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发表时间：
2021-08-04
影响因子：
4.6
通讯作者：
Tanuri A
中科院分区：
文献类型：
--
作者：
Gräf T;Bello G;Andrade P;Arantes I;Pereira JM;da Silva ABP;Veiga RV;Mariani D;Boullosa LT;Arruda MB;Fernandez JCC;Dennis AM;Rasmussen DA;Tanuri A
HIV-1已经分化成几种亚型和重组形式，在世界各地异质传播。了解病毒变异的分布及其时间动态可以帮助设计疫苗和监测病毒传播模式的变化。巴西是西方世界艾滋病毒-1流行最严重的国家之一，在该国传播的病毒的分子特征仍然不完全清楚。2008年至2017年，巴西基因分型网络（RENAGENO）对5万多个部分HIV-1基因组进行了分析。对序列进行质量过滤，每个患者删除重复序列，并使用在线工具和分子系统发育进行亚型分型。通过多项分析中计算相对风险来确定患者人口统计数据与亚型之间的关联，并通过Pearson相关检验亚型流行趋势。HIV-1B被发现是全国最普遍的亚型，除了在南部，HIV-1C普遍存在。在该国的几个地区，HIV-1C和F1的比例呈上升趋势，而HIV-1B的比例呈下降趋势。男性和受过高等教育的人更常感染艾滋病毒- 1b，而非b变体在受教育程度较低的妇女中更为普遍。我们的研究结果表明，社会人口因素在一定程度上隔离了巴西HIV-1的多样性，同时塑造了病毒传播网络。历史事件可以解释HIV-1B在男男性行为者（MSM）中优先传播，而非b变体在异性恋者中优先传播。鉴于过去10-15年巴西艾滋病病例的男女比例不断上升，HIV-1B患病率的下降令人惊讶，这表明在男男性接触者传播链中非b亚型的外显率更高。
HIV-1 has diversified into several subtypes and recombinant forms that are heterogeneously spread around the world. Understanding the distribution of viral variants and their temporal dynamics can help to design vaccines and monitor changes in viral transmission patterns. Brazil has one of the largest HIV-1 epidemics in the western-world and the molecular features of the virus circulating in the country are still not completely known. Over 50,000 partial HIV-1 genomes sampled between 2008 and 2017 by the Brazilian genotyping network (RENAGENO) were analyzed. Sequences were filtered by quality, duplicate sequences per patient were removed and subtyping was performed with online tools and molecular phylogeny. Association between patients’ demographic data and subtypes were performed by calculating the relative risk in a multinomial analysis and trends in subtype prevalence were tested by Pearson correlation. HIV-1B was found to be the most prevalent subtype throughout the country except in the south, where HIV-1C prevails. An increasing trend in the proportion of HIV-1C and F1 was observed in several regions of the country, while HIV-1B tended to decrease. Men and highly educated individuals were more frequently infected by HIV-1B and non-B variants were more prevalent among women with lower education. Our results suggest that socio-demographic factors partially segregate HIV-1 diversity in Brazil while shaping viral transmission networks. Historical events could explain a preferential circulation of HIV-1B among men who have sex with men (MSM) and non-B variants among heterosexual individuals. In view of an increasing male/female ratio of AIDS cases in Brazil in the last 10–15 years, the decrease of HIV-1B prevalence is surprising and suggests a greater penetrance of non-B subtypes in MSM transmission chains.
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影响因子：
6
作者：
Arruda MB;Boullosa LT;Cardoso CC;da Costa CM;Alves CR;de Lima ST;Kaminski HT;Aleixo AW;Esposito AO;Cavalcanti AM;Riedel M;Couto-Fernandez JC;Ferreira SB;de Oliveira IC;Portal LE;Wolf HH;Fernandes SB;de M C Pardini MI;Feiteiro MV;Tolentino FM;Diaz RS;Lopes GI;Francisco RB;Véras NM;Pires AF;Franchini M;Mesquita F;Tanuri A;HIV-BResNet
通讯作者：
HIV-BResNet
影响因子：
10.7
作者：
Nguyen LT;Schmidt HA;von Haeseler A;Minh BQ
通讯作者：
Minh BQ
影响因子：
1.6
作者：
Santos MA;Guimarães MDC;Helena ETS;Basso CR;Vale FC;Carvalho WMDES;Alves AM;Rocha GM;Acurcio FA;Ceccato MDGB;do Prado RR;Menezes PR;Nemes MIB
通讯作者：
Nemes MIB
DOI：
10.9778/cmajo.20140017
发表时间：
2014-10-01
期刊：
CMAJ open
影响因子：
--
作者：
Klein, Marina B;Young, Jim;Smaill, Fiona
通讯作者：
Smaill, Fiona
影响因子：
5.2
作者：
Ortiz Tanaka, Tayana Serpa;Leite, Thaysse Ferreira;Coimbra Motta-Castro, Ana Rita
通讯作者：
Coimbra Motta-Castro, Ana Rita