Lesions of the lateral entorhinal cortex disrupt non-spatial latent learning but spare spatial latent learning in the rat (Rattus norvegicus).
Lesions of the lateral entorhinal cortex disrupt non-spatial latent learning but spare spatial latent learning in the rat (Rattus norvegicus).
复制标题
外侧内嗅皮层的损伤破坏了大鼠（褐家鼠）的非空间潜在学习，但保留了空间潜在学习。
DOI：
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发表时间：
2013
影响因子：
1.4
通讯作者：
Jessalyn E Klein
中科院分区：
文献类型：
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作者：
Eric M. Stouffer;Jessalyn E Klein
本研究考察了外侧内嗅皮层(LEC)在非空间潜伏学习任务和空间潜伏学习任务中的作用。潜在学习是对中性信息的获取，这些信息不会立即影响行为，但可以在与动物相关的时候被回忆和利用。在前人研究的基础上，预测LEC对于非空间信息的潜在学习是必要的，但对于空间信息的潜在学习不是必需的。42只雄性SD大鼠(褐家鼠)在训练前接受局限于LEC的神经毒性损伤，或给予假(SH)损伤。然后对大鼠进行两个潜在学习任务的训练和测试：评估单线索(非空间)潜在学习的潜在线索偏好(LCP)任务和使用Barnes迷宫的空间潜在学习任务。结果表明，LEC损伤大鼠在非空间LCP任务上较SH大鼠有损害，但在空间潜伏性学习任务上无损害。因此，LEC似乎选择性地参与了非空间潜伏学习的加工，而不处理，或者至少不是空间潜伏学习所必需的。这些发现表明了LEC在信息处理中的特定作用，并提供了关于内嗅皮层功能的新信息。
The current study examined the function of the lateral entorhinal cortex (LEC) in a non-spatial latent learning task and a spatial latent learning task. Latent learning is the acquisition of neutral information that does not immediately influence behavior, but can be recalled and utilized when it becomes relevant to the animal. Based on previous research, it was predicted that the LEC would be necessary for latent learning of non-spatial information, but would not be necessary for latent learning of spatial information. Forty-two male Sprague Dawley rats (Rattus norvegicus) were either given pretraining neurotoxic lesions restricted to the LEC or were given sham (SH) lesions. The rats were then trained and tested on two latent learning tasks: the Latent Cue Preference (LCP) task which assesses single-cue (non-spatial) latent learning and a spatial latent learning task utilizing a Barnes maze. Results showed that rats with LEC lesions were impaired on the nonspatial LCP task compared to SH rats, but showed no impairment on the spatial latent learning task. Therefore, the LEC appears to be selectively involved in processing non-spatial latent learning and does not process, or is at least not necessary for, spatial latent learning. These findings indicate a specific role of the LEC in information processing and provide new information about the function of the entorhinal cortex.
影响因子：
5.3
作者：
Schultz, Heidrun;Sommer, Tobias;Peters, Jan
通讯作者：
Peters, Jan