Brain Connectivity and Neuroimaging of Social Networks in Autism.

Brain Connectivity and Neuroimaging of Social Networks in Autism.
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DOI:
10.1016/j.tics.2018.09.008
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发表时间:
2018-12
影响因子:
19.9
通讯作者:
Fishman I
Fishman I
中科院分区:
心理学1区
文献类型:
--
作者:
Müller RA;Fishman I

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社交障碍(SC)在自闭症谱系障碍(ASD)的核心诊断特征中占主导地位。神经影像学已经揭示了许多非典型的活动和连接的“社会脑”网络的研究结果,但没有共识的观点SC赤字的关键发展原因已经出现。除了方法上的挑战,更深层次的问题涉及ASD的临床标签。虽然遗传学研究还没有全面解释非综合征型ASD的原因,但它们强调临床标签包括许多病因不同的疾病。潜在的原因和病因如何汇聚到一个相对狭窄的SC赤字的问题仍然存在。只有神经影像学设计在ASD队列中搜索亚型(而不是传统的组水平设计)才能提供诊断性的信息性答案。
Impairments in social communication (SC) predominate among the core diagnostic features of autism spectrum disorders (ASDs). Neuroimaging has revealed numerous findings of atypical activity and connectivity of ‘social brain’ networks, yet no consensus view on crucial developmental causes of SC deficits has emerged. Aside from methodological challenges, the deeper problem concerns the clinical label of ASD. While genetic studies have not comprehensively explained the causes of nonsyndromic ASDs, they highlight that the clinical label encompasses many etiologically different disorders. The question of how potential causes and etiologies converge onto a comparatively narrow set of SC deficits remains. Only neuroimaging designs searching for subtypes within ASD cohorts (rather than conventional group level designs) can provide translationally informative answers.
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