Brain Connectivity and Neuroimaging of Social Networks in Autism.
Brain Connectivity and Neuroimaging of Social Networks in Autism.
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DOI:
10.1016/j.tics.2018.09.008
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发表时间:
2018-12
影响因子:
19.9
通讯作者:
Fishman I
中科院分区:
文献类型:
--
作者:
Müller RA;Fishman I
Impairments in social communication (SC) predominate among the core diagnostic features of autism spectrum disorders (ASDs). Neuroimaging has revealed numerous findings of atypical activity and connectivity of ‘social brain’ networks, yet no consensus view on crucial developmental causes of SC deficits has emerged. Aside from methodological challenges, the deeper problem concerns the clinical label of ASD. While genetic studies have not comprehensively explained the causes of nonsyndromic ASDs, they highlight that the clinical label encompasses many etiologically different disorders. The question of how potential causes and etiologies converge onto a comparatively narrow set of SC deficits remains. Only neuroimaging designs searching for subtypes within ASD cohorts (rather than conventional group level designs) can provide translationally informative answers.
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