Accent processing in dementia.
Accent processing in dementia.
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DOI：
10.1016/j.neuropsychologia.2012.05.027
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发表时间：
2012-07
期刊：
影响因子：
2.6
通讯作者：
Warren JD
中科院分区：
文献类型：
--
作者：
Hailstone JC;Ridgway GR;Bartlett JW;Goll JC;Crutch SJ;Warren JD
有口音的言语传达了说话者重要的非语言信息，同时也给大脑带来了解码非规范听觉信号的问题。在神经退行性疾病中，对非母语口音的处理很少进行研究，其大脑基础仍然知之甚少。在这里，我们研究了阿尔茨海默病（AD, n=20）和进行性非流利性失语症（PNFA, n=6）患者与健康老年人对照（n=35）的非母语国际和地区英语口音的加工。设计了一套新的评估口音理解和识别能力的方法，并对所有受试者进行了一般的神经心理学评估。在较大的AD组中，使用基于体素的MR脑图像形态学来评估口音处理性能的神经解剖学关联。与健康对照组相比，AD组和PNFA组都表现出非母语口音识别的缺陷，而PNFA组对国际口音词汇的理解能力比南方英语口音低。在个体水平上，在PNFA组中观察到的缺陷更为一致，疾病组表现出不同的口音理解障碍模式（通常在AD中的句子和PNFA中的单个单词上更为明显）。在AD组中，口音理解和识别的灰质关联在前上颞叶中被发现。研究结果表明，口音处理缺陷可能构成神经退行性疾病的特征，对理解这些疾病如何在具有挑战性的听力条件下影响声音交流具有潜在的更广泛的意义。口音理解和识别的缺陷出现在常见的痴呆综合征中。阿尔茨海默氏症和非流利失语症患者表现出明显的口音处理缺陷。在前颞叶中发现了口音加工的皮层底物。
Accented speech conveys important nonverbal information about the speaker as well as presenting the brain with the problem of decoding a non-canonical auditory signal. The processing of non-native accents has seldom been studied in neurodegenerative disease and its brain basis remains poorly understood. Here we investigated the processing of non-native international and regional accents of English in cohorts of patients with Alzheimer's disease (AD; n=20) and progressive nonfluent aphasia (PNFA; n=6) in relation to healthy older control subjects (n=35). A novel battery was designed to assess accent comprehension and recognition and all subjects had a general neuropsychological assessment. Neuroanatomical associations of accent processing performance were assessed using voxel-based morphometry on MR brain images within the larger AD group. Compared with healthy controls, both the AD and PNFA groups showed deficits of non-native accent recognition and the PNFA group showed reduced comprehension of words spoken in international accents compared with a Southern English accent. At individual subject level deficits were observed more consistently in the PNFA group, and the disease groups showed different patterns of accent comprehension impairment (generally more marked for sentences in AD and for single words in PNFA). Within the AD group, grey matter associations of accent comprehension and recognition were identified in the anterior superior temporal lobe. The findings suggest that accent processing deficits may constitute signatures of neurodegenerative disease with potentially broader implications for understanding how these diseases affect vocal communication under challenging listening conditions. ► Deficits of accent comprehension and recognition occur in common dementia syndromes. ► Alzheimer's and nonfluent aphasia patients show distinct accent processing deficits. ► Cortical substrates of accent processing were identified in anterior temporal lobe.
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DOI：
10.1037/a0013552
发表时间：
2009-04-01
影响因子：
2.1
作者：
Adank, Patti;Evans, Bronwen G.;Scott, Sophie K.
通讯作者：
Scott, Sophie K.
影响因子：
2.4
作者：
Clarke, CM;Garrett, MF
通讯作者：
Garrett, MF
影响因子：
1.6
作者：
Burda, Angela N.;Bradley-Potter, Melissa;Roehs, Andrea
通讯作者：
Roehs, Andrea
影响因子：
1.6
作者：
Burda, Angela N.;Brace, Angela;Hosch, Amanda
通讯作者：
Hosch, Amanda
影响因子：
1.6
作者：
Burda, AN;Scherz, JA;Edwards, HT
通讯作者：
Edwards, HT