Antibody responses to two Epstein-Barr virus (EBV) nuclear antigens (EBNA-1 and EBNA-2) during EBV primary infection in children born to mothers infected with human immunodeficiency virus.
Antibody responses to two Epstein-Barr virus (EBV) nuclear antigens (EBNA-1 and EBNA-2) during EBV primary infection in children born to mothers infected with human immunodeficiency virus.
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感染人类免疫缺陷病毒的母亲所生的儿童在 EBV 原发感染期间对两种 Epstein-Barr 病毒 (EBV) 核抗原（EBNA-1 和 EBNA-2）的抗体反应。
DOI：
10.1093/clinids/23.4.806
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
J. Joncas
中科院分区：
文献类型：
--
作者：
L. Pedneault;N. Lapointe;C. Alfieri;P. Ghadirian;L. Carpentier;J. Samson;J. Joncas
在感染爱泼斯坦-巴尔病毒（EBV）的不同受试者群体中，已经描述了对潜伏性爱泼斯坦-巴尔核抗原（EBNA）家族的多种抗体反应模式。本研究的目的是描述两种EBNA蛋白，EBNA-1和EBNA-2的免疫应答，在人群中的儿童谁出生的母亲感染艾滋病毒和谁经历了EBV血清转换。通过抗补体免疫荧光法对33名儿童（9名感染HIV，24名未感染）的系列血清标本中EBNA-1和EBNA-2抗体的存在进行了评估。在我们的研究中，未感染HIV的儿童中观察到的所有EBNA血清学特征与急性EBV感染的免疫活性宿主中描述的一致，即，EBNA-1抗体的发展，通常在出现EBNA-2的体液免疫应答之前。相反，在HIV感染的儿童中，EBV初次感染后，EBNA-2抗体在EBNA-1抗体后出现，并倾向于持续存在。需要进一步研究EBNA-2血清学作为HIV感染儿童预后标志物的作用。
A variety of antibody response patterns to the latent Epstein-Barr nuclear antigen (EBNA) family have been described in different groups of subjects infected with Epstein-Barr virus (EBV). The purpose of this study was to characterize the immune response to two EBNA proteins, EBNA-1 and EBNA-2, in a population of children who were born to mothers infected with HIV and who underwent EBV seroconversion. Serial serum specimens from 33 children (nine were infected with HIV, and 24 were not infected) were evaluated for the presence of antibodies to EBNA-1 and EBNA-2 by anticomplement immunofluorescence. All the EBNA serology profiles observed for children in our study who were not infected with HIV were consistent with those described for immunocompetent hosts with acute EBV infection, i.e., development of antibodies to EBNA-1, often preceded by the appearance of a humoral immune response to EBNA-2. In contrast, following EBV primary infection in HIV-infected children, antibodies to EBNA-2 arose after antibodies to EBNA-1 and tended to persist. Further studies are needed to investigate the role of EBNA-2 serology as a prognostic marker in HIV-infected children.
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慢性活动性 Epstein-Barr 病毒感染患者选择性缺乏针对 EB 核抗原成分的抗体。
DOI：
10.1093/infdis/156.1.26
发表时间：
1987
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Miller,G;Grogan,E;Rowe,D;Rooney,C;Heston,L;Eastman,R;Andiman,W;Niederman,J;Lenoir,G;Henle,W
通讯作者：
Henle,W
无并发症的传染性单核细胞增多症中抗体对 BamHI-K 核抗原反应的动力学。
DOI：
10.1093/infdis/154.2.346
发表时间：
1986
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Niederman,JC;Miller,G
通讯作者：
Miller,G
患有移植后淋巴增殖性疾病的实体器官移植受者中 Epstein-Barr 病毒潜伏基因表达和抗 EBNA 抗体反应受限的证据。
影响因子：
20.3
作者：
Cen,H;Williams,PA;McWilliams,HP;Breinig,MC;Ho,M;McKnight,JL
通讯作者：
McKnight,JL
转移 3.4 兆道尔顿 Epstein-Barr 病毒 DNA 克隆片段后，小鼠细胞中核新抗原稳定表达。
DOI：
10.1073/pnas.79.18.5688
发表时间：
1982
影响因子：
11.1
作者：
Summers,WP;Grogan,EA;Shedd,D;Robert,M;Liu,CR;Miller,G
通讯作者：
Miller,G
影响因子：
6.4
作者：
HO, M;MILLER, G;ROSENTHAL, JT
通讯作者：
ROSENTHAL, JT