Myeloid-derived suppressor cells cross-talk with B10 cells by BAFF/BAFF-R pathway to promote immunosuppression in cervical cancer.
Myeloid-derived suppressor cells cross-talk with B10 cells by BAFF/BAFF-R pathway to promote immunosuppression in cervical cancer.
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骨髓源性抑制细胞通过 BAFF/BAFF-R 通路与 B10 细胞交叉对话，促进宫颈癌的免疫抑制
DOI：
10.1007/s00262-022-03226-0
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发表时间：
2023-01
影响因子：
5.8
通讯作者：
Han Lingfei
中科院分区：
文献类型：
--
作者：
Ding Jianyi;Gan Haili;Bo, Yin;Yang Meiqin;Huang Baoyou;Hu Haoran;Li Fang;Zheng Qingliang;Han Lingfei
关键词：
Immunosuppression induced by myeloid-derived suppressor cells (MDSCs) is one of the main obstacles to the efficacy of immunotherapy for cervical cancer. Recent studies on the immunosuppressive ability of MDSCs have primarily focused on T cells, but the effect of MDSCs on B cells function is still unclear. In a study of clinical specimens, we found that the accumulation of MDSCs in patients with cervical cancer was accompanied by high expression of B cell activating factor (BAFF) on the surface and high expression of interleukin (IL)-10-producing B cells (B10) in vivo. We found that the absence of BAFF could significantly inhibit tumor growth in a cervical cancer model using BAFF KO mice. Further studies showed that abundant MDSCs in cervical cancer induced B cells to differentiate into B10 cells by regulating BAFF which acted on the BAFF receptor (BAFF-R) of them. In this process, we found that a large amount of IL-10 secreted by B10 cells can activate STAT3 signaling pathway in MDSCs, and then form a positive feedback loop to promote the differentiation of B10 cells. Therefore, this study reveals a new mechanism of BAFF-mediated mutual immune regulation between MDSCs and B cells in the occurrence and development of cervical cancer. The online version contains supplementary material available at 10.1007/s00262-022-03226-0.
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影响因子：
8.8
作者：
Holmgaard RB;Zamarin D;Li Y;Gasmi B;Munn DH;Allison JP;Merghoub T;Wolchok JD
通讯作者：
Wolchok JD
影响因子：
15.9
作者：
Matsushita, Takashi;Yanaba, Koichi;Tedder, Thomas F.
通讯作者：
Tedder, Thomas F.
影响因子：
32.4
作者：
Mizoguchi, A;Mizoguchi, E;Bhan, AK
通讯作者：
Bhan, AK
DOI：
10.1084/jem.20150950
发表时间：
2016-05-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
D'Amico L;Mahajan S;Capietto AH;Yang Z;Zamani A;Ricci B;Bumpass DB;Meyer M;Su X;Wang-Gillam A;Weilbaecher K;Stewart SA;DeNardo DG;Faccio R
通讯作者：
Faccio R
影响因子：
11.2
作者：
Sawant A;Deshane J;Jules J;Lee CM;Harris BA;Feng X;Ponnazhagan S
通讯作者：
Ponnazhagan S