Involvement of autophagy in MHC class I antigen presentation.
Involvement of autophagy in MHC class I antigen presentation.
复制标题
DOI：
10.1111/sji.12978
复制
发表时间：
2020-11
影响因子：
3.7
通讯作者：
Øynebråten I
中科院分区：
文献类型：
--
作者：
Øynebråten I
细胞表面上的MHC I类分子展示源自内源性蛋白质（自身或病毒）或源自分子、垂死细胞或病原体的内吞作用的肽。MHC I类呈递的常规抗原加工途径取决于蛋白酶体介导的蛋白质降解，然后是抗原加工相关转运蛋白（TAP）介导的所产生肽转运至内质网（ER）。在这里，肽在运输到细胞表面之前被装载到MHC I分子上。然而，出现了几种替代机制。这些包括TAP独立机制，空泡途径和自噬的参与。自噬是一种细胞内循环系统。它还作为一种防御机制，从胞质溶胶中清除病原体和受损的内吞区室。因此，自噬似乎可能与MHC I类呈递途径交叉，以警告CD8+ T细胞正在进行的细胞内感染。然而，自噬作为呈递在MHC I分子上的抗原来源的重要性仍有待确定。在这里，原始的研究论文，建议参与自噬的MHC I抗原呈递。抗原来自疱疹病毒、巨细胞病毒和衣原体。这些研究指出，自噬在免疫逃避条件下内源性蛋白质的MHC I类呈递中是重要的。由于自噬是一种受调控的过程，其在例如模式识别受体（PRR）的激活后被诱导，因此在未来的研究中，当旨在确认自噬在MHC I类抗原呈递中的重要性时，将相关刺激条件与原代细胞一起使用将是至关重要的。
MHC class I molecules on the cellular surface display peptides that either derive from endogenous proteins (self or viral), or from endocytosis of molecules, dying cells or pathogens. The conventional antigen‐processing pathway for MHC class I presentation depends on proteasome‐mediated degradation of the protein followed by transporter associated with antigen‐processing (TAP)‐mediated transport of the generated peptides into the endoplasmic reticulum (ER). Here, peptides are loaded onto MHC I molecules before transportation to the cell surface. However, several alternative mechanisms have emerged. These include TAP‐independent mechanisms, the vacuolar pathway and involvement of autophagy. Autophagy is a cell intrinsic recycling system. It also functions as a defence mechanism that removes pathogens and damaged endocytic compartments from the cytosol. Therefore, it appears likely that autophagy would intersect with the MHC class I presentation pathway to alarm CD8+ T cells of an ongoing intracellular infection. However, the importance of autophagy as a source of antigen for presentation on MHC I molecules remains to be defined. Here, original research papers which suggest involvement of autophagy in MHC I antigen presentation are reviewed. The antigens are from herpesvirus, cytomegalovirus and chlamydia. The studies point towards autophagy as important in MHC class I presentation of endogenous proteins during conditions of immune evasion. Because autophagy is a regulated process which is induced upon activation of, for example, pattern recognition receptors (PRRs), it will be crucial to use relevant stimulatory conditions together with primary cells when aiming to confirm the importance of autophagy in MHC class I antigen presentation in future studies.
登录
查看更多内容
DOI：
10.1083/jcb.201706157
发表时间：
2018-03-05
期刊：
The Journal of cell biology
影响因子：
--
作者：
Cadwell K;Debnath J
通讯作者：
Debnath J
DOI：
10.3390/v7122957
发表时间：
2015-12-11
期刊：
Viruses
影响因子：
--
作者：
Cooper RS;Heldwein EE
通讯作者：
Heldwein EE
DOI：
10.1038/s41579-018-0003-6
发表时间：
2018-06
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
Choi Y;Bowman JW;Jung JU
通讯作者：
Jung JU
DOI：
10.1073/pnas.92.23.10516
发表时间：
1995-11-07
影响因子：
11.1
作者：
CHOU, J;CHEN, JJ;ROIZMAN, B
通讯作者：
ROIZMAN, B
影响因子：
20.3
作者：
Fonteneau, JF;Kavanagh, DG;Larsson, M
通讯作者：
Larsson, M