A therapeutic approach to nasopharyngeal carcinomas by DNAzymes targeting EBV LMP-1 gene.
A therapeutic approach to nasopharyngeal carcinomas by DNAzymes targeting EBV LMP-1 gene.
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靶向 EBV LMP-1 基因的 DNAzyme 治疗鼻咽癌
DOI：
10.3390/molecules15096127
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发表时间：
2010-09-01
期刊：
影响因子：
--
通讯作者：
Sun LQ
中科院分区：
文献类型：
--
作者：
Yang L;Lu Z;Ma X;Cao Y;Sun LQ
Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) has been known to have oncogenic properties during latent infection in nasopharyngeal carcinoma (NPC). Genetic manipulation of LMP1 expression may provide a novel strategy for the treatment of NPC. DNAzymes are synthetic, single-stranded DNA catalysts that can be engineered to bind and cleave the target mRNA of a disease-causing gene. By targeting the LMP1 mRNA, we successfully obtained a phosphorothioate-modified ‘‘10–23’’ DNAzyme namely DZ1, through screening a series of DNAzymes. DZ1 could significantly down-regulate the expression of LMP1 in NPC cells, inhibit cell proliferation, metastasis, promote apoptosis and enhance radiosensitivity of NPC through interfering signal pathways which are abnormally activated by LMP1, including NF-κB, AP-1 and STAT3 signal pathways. Together, interfering LMP1 signaling pathway could be a promising strategy to target the malignant phenotypes of NPC.
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DOI：
10.1002/hed.20833
发表时间：
2008-07
影响因子：
2.9
作者：
Chou, Josephine;Lin, Yu-Ching;Kim, Jae;You, Liang;Xu, Zhidong;He, Biao;Jablons, David M.
通讯作者：
Jablons, David M.
影响因子：
--
作者：
BREAKER, RR;JOYCE, GF
通讯作者：
JOYCE, GF
影响因子：
46.9
作者：
Cairns, MJ;Hopkins, TM;Sun, LQ
通讯作者：
Sun, LQ
DOI：
10.1089/108729002761381276
发表时间：
2002-10-01
期刊：
ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT
影响因子：
--
作者：
Dass, CR;Saravolac, EG;Sun, LQ
通讯作者：
Sun, LQ
影响因子：
5.4
作者：
Dawson, Christopher W.;Laverick, Louise;Young, Lawrence S.
通讯作者：
Young, Lawrence S.