Temporal assessment of lesion morphology on radiological images beyond lesion volumes-a proof-of-principle study.
Temporal assessment of lesion morphology on radiological images beyond lesion volumes-a proof-of-principle study.
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超越病变体积的放射图像上病变形态的时间评估——原理验证研究。
DOI：
10.1007/s00330-022-08894-1
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发表时间：
2022-12
影响因子：
5.9
通讯作者：
中科院分区：
文献类型：
--
作者：
建立一个总体框架，以评估放射学图像上病变形态的时间变化（超出体积变化），并测试可卡因戒断是否会改变连续冠状动脉CT血管造影（CTA）上的冠状动脉斑块结构。患有人类免疫缺陷病毒（HIV）感染的慢性可卡因使用者前瞻性地参加了以现金为基础的应急管理，以实现可卡因戒断。参与者在基线、招募后6个月和12个月接受冠状动脉CTA。我们分割了所有冠状动脉斑块，并提取了1103个放射组学特征。我们实施了加权相关网络分析，以获得一致的本征放射组学特征（命名为不同的颜色），并使用线性混合模型和中介分析，以评估可卡因戒断是否影响斑块形态校正临床变量和斑块体积，以及血清生物标志物是否因果介导这些变化。此外，我们使用贝叶斯隐马尔可夫网络变点分析，以评估潜在的重新布线的radiomic网络。69名PLWH（中位年龄55 IQR：52-59岁，19%女性）完成了研究，其中26人完全戒烟。得到20个一致的本征放射组学特征。戒烟显著影响粉红色和青色特征（分别为-0.04 CI：[-0.06;-0.02]，p=0.0009; 0.03 CI：[0.001; 0.04]，p=0.0017）。这些作用通过内皮素-1水平的变化介导。在禁欲的人，我们观察到显着的重新布线的潜在radiomic签名网络。使用我们提出的框架，我们发现1年的可卡因戒断显着改变特定的潜在冠状动脉斑块的形态学特征和重新布线的潜在形态网络以上和超越斑块体积和临床特征的变化。
To develop a general framework to assess temporal changes in lesion morphology on radiological images beyond volumetric changes, and to test whether cocaine abstinence changes coronary plaque structure on serial coronary CT angiography (CTA). Chronic cocaine users with human immunodeficiency virus (HIV) infection were prospectively enrolled to undergo cash-based contingency management to achieve cocaine abstinence. Participants underwent coronary CTA at baseline, 6- and 12-months following recruitment. We segmented all coronary plaques and extracted 1103 radiomic features. We implemented weighted correlation network analysis to derive consensus eigen radiomic features (named as different colors) and used linear mixed models and mediation analysis to assess whether cocaine abstinence affects plaque morphology correcting for clinical variables and plaque volumes and whether serum biomarkers causally mediate these changes. Furthermore, we used Bayesian hidden Markov network changepoint analysis to assess potential rewiring of the radiomic network. 69 PLWH (median age 55 IQR: 52-59 years, 19% female) completed the study, of whom 26 achieved total abstinence. 20 consensus eigen radiomic features were derived. Cocaine abstinence significantly affected the pink and cyan eigen features (−0.04 CI: [−0.06; −0.02], p=0.0009; 0.03 CI: [0.001; 0.04], p=0.0017, respectively). These effects were mediated through changes in Endothelin-1 levels. In abstinent individuals we observed significant rewiring of the latent radiomic signature network. Using our proposed framework, we found 1 year cocaine abstinence to significantly change specific latent coronary plaque morphological features and rewire the latent morphologic network above and beyond changes in plaque volumes and clinical characteristics.
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DOI：
10.1016/s0140-6736(18)32203-7
发表时间：
2018-11-10
期刊：
Lancet (London, England)
影响因子：
--
作者：
GBD 2017 Causes of Death Collaborators
通讯作者：
GBD 2017 Causes of Death Collaborators
WGCNA：用于加权相关网络分析的 R 包。
影响因子：
3
作者：
Langfelder P;Horvath S
通讯作者：
Horvath S
DOI：
10.1161/circimaging.117.006843
发表时间：
2017-12
期刊：
Circulation. Cardiovascular imaging
影响因子：
--
作者：
Kolossváry M;Karády J;Szilveszter B;Kitslaar P;Hoffmann U;Merkely B;Maurovich-Horvat P
通讯作者：
Maurovich-Horvat P
影响因子：
19.7
作者：
Berenguer, Roberto;del Rosario Pastor-Juan, Maria;Sabater, Sebastia
通讯作者：
Sabater, Sebastia
影响因子：
24
作者：
Roth GA;Johnson C;Abajobir A;Abd-Allah F;Abera SF;Abyu G;Ahmed M;Aksut B;Alam T;Alam K;Alla F;Alvis-Guzman N;Amrock S;Ansari H;Ärnlöv J;Asayesh H;Atey TM;Avila-Burgos L;Awasthi A;Banerjee A;Barac A;Bärnighausen T;Barregard L;Bedi N;Belay Ketema E;Bennett D;Berhe G;Bhutta Z;Bitew S;Carapetis J;Carrero JJ;Malta DC;Castañeda-Orjuela CA;Castillo-Rivas J;Catalá-López F;Choi JY;Christensen H;Cirillo M;Cooper L Jr;Criqui M;Cundiff D;Damasceno A;Dandona L;Dandona R;Davletov K;Dharmaratne S;Dorairaj P;Dubey M;Ehrenkranz R;El Sayed Zaki M;Faraon EJA;Esteghamati A;Farid T;Farvid M;Feigin V;Ding EL;Fowkes G;Gebrehiwot T;Gillum R;Gold A;Gona P;Gupta R;Habtewold TD;Hafezi-Nejad N;Hailu T;Hailu GB;Hankey G;Hassen HY;Abate KH;Havmoeller R;Hay SI;Horino M;Hotez PJ;Jacobsen K;James S;Javanbakht M;Jeemon P;John D;Jonas J;Kalkonde Y;Karimkhani C;Kasaeian A;Khader Y;Khan A;Khang YH;Khera S;Khoja AT;Khubchandani J;Kim D;Kolte D;Kosen S;Krohn KJ;Kumar GA;Kwan GF;Lal DK;Larsson A;Linn S;Lopez A;Lotufo PA;El Razek HMA;Malekzadeh R;Mazidi M;Meier T;Meles KG;Mensah G;Meretoja A;Mezgebe H;Miller T;Mirrakhimov E;Mohammed S;Moran AE;Musa KI;Narula J;Neal B;Ngalesoni F;Nguyen G;Obermeyer CM;Owolabi M;Patton G;Pedro J;Qato D;Qorbani M;Rahimi K;Rai RK;Rawaf S;Ribeiro A;Safiri S;Salomon JA;Santos I;Santric Milicevic M;Sartorius B;Schutte A;Sepanlou S;Shaikh MA;Shin MJ;Shishehbor M;Shore H;Silva DAS;Sobngwi E;Stranges S;Swaminathan S;Tabarés-Seisdedos R;Tadele Atnafu N;Tesfay F;Thakur JS;Thrift A;Topor-Madry R;Truelsen T;Tyrovolas S;Ukwaja KN;Uthman O;Vasankari T;Vlassov V;Vollset SE;Wakayo T;Watkins D;Weintraub R;Werdecker A;Westerman R;Wiysonge CS;Wolfe C;Workicho A;Xu G;Yano Y;Yip P;Yonemoto N;Younis M;Yu C;Vos T;Naghavi M;Murray C
通讯作者：
Murray C