Tumour-infiltrating inflammatory and immune cells in patients with extrahepatic cholangiocarcinoma.
Tumour-infiltrating inflammatory and immune cells in patients with extrahepatic cholangiocarcinoma.
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肝外胆管癌患者的肿瘤炎性和免疫细胞。
DOI：
10.1038/bjc.2017.401
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发表时间：
2018-01
影响因子：
8.8
通讯作者：
Baba H
中科院分区：
文献类型：
--
作者：
Kitano Y;Okabe H;Yamashita YI;Nakagawa S;Saito Y;Umezaki N;Tsukamoto M;Yamao T;Yamamura K;Arima K;Kaida T;Miyata T;Mima K;Imai K;Hashimoto D;Komohara Y;Chikamoto A;Ishiko T;Baba H
肿瘤微环境的炎症和免疫特性具有治疗意义。本研究的目的是探讨对人肝外胆管癌（ECC）疾病进展的临床影响。在2000年至2014年间，共有114例ECC患者接受了根治性切除。采用免疫组化方法检测肿瘤浸润的CD66b+中性粒细胞（TANs；肿瘤相关中性粒细胞）、CD163+ M2巨噬细胞（TAMs；肿瘤相关巨噬细胞）、CD8+ T细胞和FOXP3+调节性T细胞（Tregs），并评估其与患者临床病理特征和预后的关系。肿瘤相关中性粒细胞与CD8+ T细胞呈负相关（P=0.0001），与Tregs呈正相关（P=0.001）。高TANs （P=0.01）、低CD8+ T细胞（P=0.02）和高Tregs （P=0.04）与总生存期（OS）差显著相关。来自肿瘤内炎症和免疫细胞整合的高风险特征与较差的无复发生存率（P=0.01）和OS （P=0.0008）显著相关。高危特征与术后远处转移相关。此外，复发后对吉西他滨为基础的化疗的耐药性与高风险特征有关。我们的数据显示，肿瘤浸润性炎症细胞和免疫细胞可能在ECC进展中起关键作用，高风险特征预示ECC患者预后不良。
Inflammation and immune characteristics of the tumour microenvironment have therapeutic significance. The aim of this study was to investigate the clinical impact on disease progression in human extrahepatic cholangiocarcinoma (ECC). A total of 114 consecutive ECC patients with curative resection between 2000 and 2014 were enrolled. Tumour infiltrating CD66b+ neutrophils (TANs; tumour associated neutrophils), CD163+ M2 macrophages (TAMs; tumour associated macrophages), CD8+ T cells, and FOXP3+ regulatory T cells (Tregs) were assayed by immunohistochemistry, and their relationships with patient clinicopathological characteristics and prognosis were evaluated. Tumour associated neutrophils were inversely correlated with CD8+ T cells (P=0.0001) and positively correlated with Tregs (P=0.001). High TANs (P=0.01), low CD8+ T cells (P=0.02), and high Tregs (P=0.04) were significantly associated with poor overall survival (OS). A high-risk signature, derived from integration of intratumoural inflammatory and immune cells, was significantly associated with poor recurrence-free survival (P=0.01) and OS (P=0.0008). A high-risk signature was correlated with postoperative distant metastases. Furthermore, a high-risk signature was related to the resistance to gemcitabine-based chemotherapy used after recurrence. Our data showed that tumour infiltrating inflammatory and immune cells may play a pivotal role in ECC progression and a high-risk signature predicted poor prognosis in ECC patients.
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影响因子：
3.7
作者：
Gu, Fang-Ming;Gao, Qiang;Zhou, Jian
通讯作者：
Zhou, Jian
影响因子：
45.3
作者：
Jensen, Hanne Krogh;Donskov, Frede;von der Maase, Hans
通讯作者：
von der Maase, Hans
DOI：
10.1056/nejmoa0804525
发表时间：
2008-11-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hoshida Y;Villanueva A;Kobayashi M;Peix J;Chiang DY;Camargo A;Gupta S;Moore J;Wrobel MJ;Lerner J;Reich M;Chan JA;Glickman JN;Ikeda K;Hashimoto M;Watanabe G;Daidone MG;Roayaie S;Schwartz M;Thung S;Salvesen HB;Gabriel S;Mazzaferro V;Bruix J;Friedman SL;Kumada H;Llovet JM;Golub TR
通讯作者：
Golub TR
影响因子：
--
作者：
Fontugne J;Augustin J;Pujals A;Compagnon P;Rousseau B;Luciani A;Tournigand C;Cherqui D;Azoulay D;Pawlotsky JM;Calderaro J
通讯作者：
Calderaro J
影响因子：
64.8
作者：
Coffelt, Seth B.;Kersten, Kelly;Doornebal, Chris W.;Weiden, Jorieke;Vrijland, Kim;Hau, Cheei-Sing;Verstegen, Niels J. M.;Ciampricotti, Metamia;Hawinkels, Lukas J. A. C.;Jonkers, Jos;de Visser, Karin E.
通讯作者：
de Visser, Karin E.