Ticlopidine and Aspirin Fail to Suppress the Increased Platelet Aggregability That Follows Percutaneous Coronary Interventions
Ticlopidine and Aspirin Fail to Suppress the Increased Platelet Aggregability That Follows Percutaneous Coronary Interventions
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噻氯匹定和阿司匹林无法抑制经皮冠状动脉介入治疗后血小板聚集性的增加
DOI：
10.1023/a:1026551409350
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发表时间：
2000
影响因子：
4
通讯作者：
F. Andreotti
中科院分区：
文献类型：
--
作者：
D. Fischetti;A. Sciahbasi;A. Leone;G. Niccoli;G. Schiavoni;C. Trani;M. Mazzari;F. Andreotti
先前的研究表明，经皮腔内冠状动脉成形术（PTCA）与血小板活化有关。尚不清楚噻氯匹定与阿司匹林联合使用是否可以预防 PTCA 后血小板聚集性的增强。本研究的目的是评估接受噻氯匹定和阿司匹林治疗的慢性稳定型心绞痛患者在选择性 PTCA 前后的全血血小板聚集性。我们研究了 16 名转诊进行择期 PTCA 的患者，口服阿司匹林和噻氯匹定治疗≥72 小时（第 1 组），以及 10 名转诊进行诊断性冠状动脉造影的患者，仅口服阿司匹林治疗（第 2 组）。 PTCA 开始时静脉推注肝素。使用 PFA 100® 系统在基线和手术后 24 小时评估两组的血小板聚集性。该方法测量流动的全血封闭胶原蛋白和二磷酸腺苷 (ADP) 涂层环所需的时间，时间越短表明聚集性越好。在两组中，与基线相比，手术后血小板聚集性均显着增加：第 1 组手术前为 104±30 秒，24 小时时为 88±24 秒（p=0.03）；第 2 组为术前 84±16 秒，24 小时时为 69±14 秒（p=0.004）。与第 2 组相比，第 1 组患者在基线时表现出聚集性降低的趋势 (p=0.06)，并且在手术后 24 小时内聚集性显着降低 (p=0.03)。与单独使用阿司匹林相比，噻氯匹定和阿司匹林可降低全血血小板聚集性，但无法抑制 PTCA 后 24 小时发生的聚集性增加。
Previous studies indicate that percutaneous transluminal coronary angioplasty (PTCA) is associated with platelet activation. It is not well-established whether enhanced platelet aggregability after PTCA is prevented by the association of ticlopidine with aspirin. The aim of this study was to evaluate whole blood platelet aggregability before and after elective PTCA in patients with chronic stable angina receiving ticlopidine and aspirin. We studied 16 patients referred for elective PTCA, treated for≥72 hours with oral aspirin and ticlopidine (group 1), and 10 patients referred for diagnostic coronary angiography, treated with oral aspirin alone (group 2). An intravenous bolus of heparin was administered at the start of PTCA. In both groups, platelet aggregability was assessed at baseline and 24 hours after the procedure, using the PFA 100® system. This method measures the time required for flowing whole blood to occlude a collagen and adenosine diphosphate (ADP)–coated ring, shorter times indicating greater aggregability. In both groups, platelet aggregability after the procedure was significantly increased compared with baseline: 104±30 seconds before versus 88±24 seconds at 24 hours in group 1 (p=0.03) and 84±16 seconds before versus 69±14 seconds at 24 hours in group 2 (p=0.004). Group 1 patients, compared with group 2, showed a trend toward reduced aggregability at baseline (p=0.06) and significantly lower aggregability 24 hours after the procedure (p=0.03). Ticlopidine and aspirin reduce whole-blood platelet aggregability compared with aspirin alone but fail to suppress the increased aggregability that occurs 24 hours after PTCA.
经皮腔内球囊血管成形术后人冠状动脉中凝血酶的产生。
影响因子：
24
作者：
Marmur,JD;Merlini,PA;Sharma,SK;Khaghan,N;Torre,SR;Israel,DH;Ardissino,D;Ambrose,JA
通讯作者：
Ambrose,JA
DOI：
10.1073/pnas.86.8.2839
发表时间：
1989-04-01
影响因子：
11.1
作者：
WILCOX, JN;SMITH, KM;GORDON, D
通讯作者：
GORDON, D