CaZnOS:Nd(3+) Emits Tissue-Penetrating near-Infrared Light upon Force Loading.
CaZnOS:Nd(3+) Emits Tissue-Penetrating near-Infrared Light upon Force Loading.
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CaZnOS:Nd3 在受力加载时发出组织穿透的近红外光
DOI：
10.1021/acsami.8b02530
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发表时间：
2018-05-02
影响因子：
9.5
通讯作者：
Mao C
中科院分区：
文献类型：
--
作者：
Li L;Wondraczek L;Li L;Zhang Y;Zhu Y;Peng M;Mao C
机械发光（ML）材料是机械-光学转换器，可以在外部机械刺激下发光。所有现有的ML材料只能发射从近紫外到红光的光，这超出了生物力学成像所需的近红外（NIR）窗口。尚未进行关于将具有NIR区域中的光致发光（PL）的稀土（RE）离子掺杂到化合物中以形成响应于外力而发射NIR光的ML材料的研究。在这里，我们表明，掺杂稀土离子与近红外PL到无机化合物通常不会导致形成的近红外ML材料，这只能实现在Nd 3+离子和CaZnOS化合物的组合之间的组合，我们研究。新发现的NIR ML材料（CaZnOS：Nd 3+）具有生物相容性，可以在第一和第二组织穿透生物成像窗口内有效地将机械应力转换为NIR光。其NIR ML发射出现在非常低的力阈值（即使当材料轻微摇晃时），随着力的增加（高达>5 kN）敏感地线性增加，并且可以穿透组织深至>22 mm以实现生物力学检测。这种力响应行为是高度可再现的。因此，CaZnOS：Nd 3+是一种新的潜在的超灵敏生物力学探针，并将ML应用范围扩展到体内生物成像。
Mechanoluminescent (ML) materials are mechano-optical converters that can emit light under an external mechanical stimulus. All the existing ML materials can only emit light from near ultraviolet to red, which is outside the near-infrared (NIR) windows desired for biomechanical imaging. No studies have been done on doping rare earth (RE) ions with photoluminescence (PL) in the NIR region into a compound to form a ML material that emits NIR light in response to an external force. Here, we show that doping RE ions with a NIR PL into an inorganic compound does not usually result in the formation of a NIR ML material, which can only be achieved in the combination of Nd3+ ions and a CaZnOS compound among the combinations we studied. The newly discovered NIR ML material (CaZnOS:Nd3+) is biocompatible and can efficiently convertmechanical stress into NIR light over the first and second tissue-penetrating bioimaging window. Its NIR ML emission appeared at a very low force threshold (even when the material was shaken slightly), increased sensitively and linearly with the increase in the force (up to >5 kN), and could penetrate the tissue as deep as >22 mm to enable biomechanical detection. Such a force-responsive behavior is highly reproducible. Hence, CaZnOS:Nd3+ is a new potential ultrasensitive biomechanical probe and expands the ML application horizons into in vivo bioimaging.
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影响因子：
8.6
作者：
Duan, C. J.;Delsing, A. C. A.;Hintzen, H. T.
通讯作者：
Hintzen, H. T.
影响因子：
16.6
作者：
Yang, Yanmei;Shao, Qing;Xing, Bengang
通讯作者：
Xing, Bengang
影响因子：
4.6
作者：
Sambrook, Timothy;Smura, Catherine F.;Halasyamani, P. Shiv
通讯作者：
Halasyamani, P. Shiv
DOI：
10.1249/01.mss.0000176686.18683.64
发表时间：
2005-11-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Besier, TF;Gold, GE;Delp, SL
通讯作者：
Delp, SL
影响因子：
3.7
作者：
Wang Y;Li Z;Wong DW;Zhang M
通讯作者：
Zhang M