Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress.
Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress.
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DOI：
10.1016/j.psyneuen.2009.03.013
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发表时间：
2009-09
影响因子：
3.7
通讯作者：
Hillard, Cecilia J.
中科院分区：
文献类型：
--
作者：
Hill, Matthew N.;Miller, Gregory E.;Carrier, Erica J.;Gorzalka, Boris B.;Hillard, Cecilia J.
已知中枢内源性大麻素信号对应激刺激有反应;然而，迄今为止还没有研究表征应激对外周内源性大麻素含量的影响。本研究检测了内源性大麻素配体N-花生四烯酸乙醇酰胺的血清含量，（anandamide; AEA）和2-花生四烯酰甘油（2-AG）以及非大麻素N-酰基乙醇胺（NAE）分子棕榈酰乙醇胺（PEA）和油酰乙醇胺（OEA）在基础条件下，在特里尔社会压力测试（TSST）后立即进行，此后30分钟，在15名被诊断患有重度抑郁症的无药物女性中，和15名健康匹配的对照组。基础血清浓度的AEA和2-AG，但不PEA或OEA，显着降低女性抑郁症相对于匹配的对照组，表明外周内源性大麻素活性的赤字。TSST后即刻，血清2-AG浓度与基线相比升高;血清AEA浓度在该时间点不变。停止TSST后30分钟，PEA和OEA的血清浓度显著低于基线。这些反应的幅度在抑郁症和对照组之间没有差异。这些是第一个数据表明，外周内源性大麻素/NAE系统是响应于暴露于压力。
Central endocannabinoid signaling is known to be responsive to stressful stimuli; however, there is no research to date characterizing the effects of stress on peripheral endocannabinoid content. The current study examined serum content of the endocannabinoid ligands N-arachidonylethanolamide (anandamide; AEA) and 2-arachidonoylglycerol (2-AG), and the non-cannabinoid N-acyl ethanolamine (NAE) molecules palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) under basal conditions, immediately following the Trier Social Stress Test (TSST), and 30 min thereafter, in fifteen medication-free women diagnosed with major depression, and fifteen healthy matched controls. Basal serum concentrations of AEA and 2-AG, but not PEA or OEA, were significantly reduced in women with major depression relative to matched controls, indicating a deficit in peripheral endocannabinoid activity. Immediately following the TSST, serum 2-AG concentrations were increased compared to baseline; serum AEA concentration was unchanged at this time point. Serum concentrations of PEA and OEA were significantly lower than baseline 30 min following the cessation of the TSST. The magnitude of these responses did not differ between depressed and control subjects. These are the first data to demonstrate that the peripheral endocannabinoid/NAE system is responsive to exposure to stress.
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影响因子：
64.8
作者：
Fu, J;Gaetani, S;Piomelli, D
通讯作者：
Piomelli, D
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3.6
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