In vitro evaluation of antimicrobial compounds for cysticidal activity against Acanthamoeba.
In vitro evaluation of antimicrobial compounds for cysticidal activity against Acanthamoeba.
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抗菌化合物对棘阿米巴杀囊活性的体外评价。
DOI：
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Daniel B. Jones
中科院分区：
文献类型：
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作者：
M. S. Osato;Nettie M. Robinson;Kirk R. Wilhelmus;Daniel B. Jones
阿米巴性角膜炎呈现出治疗困境，因为棘阿米巴与耐格里阿米巴不同，它会在受感染的组织中形成包囊。迄今为止，药物治疗的结果令人失望，棘阿米巴角膜炎的最佳治疗方案尚未确定。临床治愈需要使用已知具有眼毒性作用的药物并结合手术操作来根除包膜阿米巴原虫。具有体外杀囊活性的抗感染剂包括巴龙霉素、新霉素、酮康唑、那他霉素和环吡酮胺，但没有药物被证明对所有棘阿米巴分离株均有效。用羟乙磺酸丙烷脒加巴龙霉素或新霉素治疗阿米巴包囊可产生轻微的附加杀包囊作用。多种因素，包括不同的临床表现和缺乏用于杀囊活性测定的标准化体外技术，导致体外活性和体内功效之间缺乏相关性。
Amebic keratitis presents a therapeutic dilemma because Acanthamoeba, unlike Naegleria, encysts in infected tissues. To date, the results of medical therapy have been disappointing, and the optimal medical regimen for acanthamoeba keratitis is yet to be defined. Clinical cure necessitates eradication of the encysted amebae with medications known to have ocular toxic effects in combination with surgical maneuvers. Antiinfective agents possessing in vitro cysticidal activity include paromomycin, neomycin, ketoconazole, natamycin, and ciclopirox olamine, but no agent has been shown to be uniformly effective against all isolates of Acanthamoeba. Treatment of amebic cysts with propamidine isethionate plus either paromomycin or neomycin has produced slightly additive cysticidal effects. Multiple factors, including the varied clinical presentation and the lack of standardized in vitro techniques for the assay of cysticidal activity, account for the lack of correlation between in vitro activity and in vivo efficacy.
丙烷脒的角膜毒性。
DOI：
10.1001/archopht.1988.01060130074031
发表时间：
1988
期刊：
Archives of ophthalmology (Chicago, Ill. : 1960)
影响因子：
--
作者：
Johns,KJ;Head,WS;O'Day,DM
通讯作者：
O'Day,DM
放射状角膜神经炎是棘阿米巴角膜炎的症状。
影响因子：
13.7
作者：
Moore,MB;McCulley,JP;Kaufman,HE;Robin,JB
通讯作者：
Robin,JB