Image-guided cancer surgery using near-infrared fluorescence.

Image-guided cancer surgery using near-infrared fluorescence.
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DOI:
10.1038/nrclinonc.2013.123
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发表时间:
2013-09
期刊:
Nature reviews. Clinical oncology
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Paradigm shifts in surgery arise when surgeons are empowered to perform surgery faster, better, and/or less expensively. Optical imaging that exploits invisible near-infrared fluorescent light has the potential to improve cancer surgery outcomes while minimizing anesthesia time and lowering healthcare costs. Because of this, the last few years have witnessed an explosion of proof-of-concept clinical trials in the field. In this review, we introduce the concept of near-infrared fluorescence imaging for cancer surgery, review the clinical trial literature to date, outline the key issues pertaining to imaging system and contrast agent optimization, discuss limitations and leverage, and provide a framework for making the technology available for the routine care of cancer patients in the near future.
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