Low rate of SARS-CoV-2 incident infection identified by weekly screening PCR in a prospective year-long cohort study.
Low rate of SARS-CoV-2 incident infection identified by weekly screening PCR in a prospective year-long cohort study.
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DOI：
10.1371/journal.pone.0274078
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
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作者：
无症状和无症状的SARS-CoV-2感染可能有助于持续的社区传播，然而，在低风险人群中对无症状个人进行常规筛查的好处尚不清楚。为了确定SARS-CoV-2感染，对553名血清阴性的人进行了52周的前瞻性跟踪调查。从2020年4月至2021年7月，参与者每周提交自行收集的鼻拭子进行RT-PCR，并完成症状和暴露调查。在553名参与者中有9名(1.6%)发现了偶发的SARS2-CoV-2感染。将SARS2-CoV-2(+)和SARS2-CoV-2(-)参与者进行比较，发现家庭外密切接触者明显更多(中位数：5比3；p=0.005)。未接种/部分接种的参与者的感染率高于完全接种的参与者(9/7,679比0/6,845人周；p=0.004)。在通知阳性检测结果时，8例患者出现症状，1例患者出现症状前症状。这些数据表明，RTPCR每周监测SARS2-CoV2并没有有效地检测到未接种疫苗的参与者中的症状前感染。
Asymptomatic and pre-symptomatic SARS-CoV-2 infections may contribute to ongoing community transmission, however, the benefit of routine screening of asymptomatic individuals in low-risk populations is unclear. To identify SARS-CoV-2 infections 553 seronegative individuals were prospectively followed for 52 weeks. From 4/2020-7/2021, participants submitted weekly self-collected nasal swabs for rtPCR and completed symptom and exposure surveys. Incident SARS2-CoV-2 infections were identified in 9/553 (1.6%) participants. Comparisons of SARS2-CoV-2(+) to SARS2-CoV-2(-) participants revealed significantly more close contacts outside the household (median: 5 versus 3; p = 0.005). The incidence of infection was higher among unvaccinated/partially vaccinated than among fully vaccinated participants (9/7,679 versus 0/6,845 person-weeks; p = 0.004). At notification of positive test result, eight cases were symptomatic and one pre-symptomatic. These data suggest that weekly SARS2-CoV2 surveillance by rtPCR did not efficiently detect pre-symptomatic infections in unvaccinated participants.
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影响因子：
9.3
作者：
Hellewell J;Russell TW;SAFER Investigators and Field Study Team;Crick COVID-19 Consortium;CMMID COVID-19 working group;Beale R;Kelly G;Houlihan C;Nastouli E;Kucharski AJ
通讯作者：
Kucharski AJ
DOI：
10.1056/nejmoa2110345
发表时间：
2021-11-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Thomas SJ;Moreira ED Jr;Kitchin N;Absalon J;Gurtman A;Lockhart S;Perez JL;Pérez Marc G;Polack FP;Zerbini C;Bailey R;Swanson KA;Xu X;Roychoudhury S;Koury K;Bouguermouh S;Kalina WV;Cooper D;Frenck RW Jr;Hammitt LL;Türeci Ö;Nell H;Schaefer A;Ünal S;Yang Q;Liberator P;Tresnan DB;Mather S;Dormitzer PR;Şahin U;Gruber WC;Jansen KU;C4591001 Clinical Trial Group
通讯作者：
C4591001 Clinical Trial Group
影响因子：
13.8
作者：
Forster J;Streng A;Rudolph P;Rücker V;Wallstabe J;Timme S;Pietsch F;Hartmann K;Krauthausen M;Schmidt J;Ludwig T;Gierszewski D;Jans T;Engels G;Weißbrich B;Romanos M;Dölken L;Heuschmann P;Härtel C;Gágyor I;Figge MT;Kurzai O;Liese J;Wü-KiTa-CoV Study Group
通讯作者：
Wü-KiTa-CoV Study Group
影响因子：
64.8
作者：
Mlcochova P;Kemp SA;Dhar MS;Papa G;Meng B;Ferreira IATM;Datir R;Collier DA;Albecka A;Singh S;Pandey R;Brown J;Zhou J;Goonawardane N;Mishra S;Whittaker C;Mellan T;Marwal R;Datta M;Sengupta S;Ponnusamy K;Radhakrishnan VS;Abdullahi A;Charles O;Chattopadhyay P;Devi P;Caputo D;Peacock T;Wattal C;Goel N;Satwik A;Vaishya R;Agarwal M;Indian SARS-CoV-2 Genomics Consortium (INSACOG);Genotype to Phenotype Japan (G2P-Japan) Consortium;CITIID-NIHR BioResource COVID-19 Collaboration;Mavousian A;Lee JH;Bassi J;Silacci-Fegni C;Saliba C;Pinto D;Irie T;Yoshida I;Hamilton WL;Sato K;Bhatt S;Flaxman S;James LC;Corti D;Piccoli L;Barclay WS;Rakshit P;Agrawal A;Gupta RK
通讯作者：
Gupta RK
影响因子：
4.6
作者：
Dewhurst RE;Heinrich T;Watt P;Ostergaard P;Marimon JM;Moreira M;Houldsworth PE;Rudrum JD;Wood D;Kõks S
通讯作者：
Kõks S