Instant and supersaturated dissolution of naproxen and sesamin (poorly water-soluble drugs and supplements) nanoparticles prepared by continuous expansion of liquid carbon dioxide solution through long dielectric nozzle
Instant and supersaturated dissolution of naproxen and sesamin (poorly water-soluble drugs and supplements) nanoparticles prepared by continuous expansion of liquid carbon dioxide solution through long dielectric nozzle
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通过长介电喷嘴连续膨胀液态二氧化碳溶液制备的萘普生和芝麻素（难溶于水的药物和补充剂）纳米颗粒的即时和过饱和溶解
DOI：
10.1007/s11051-012-1251-4
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Koichi Nakahara
中科院分区：
文献类型：
--
作者：
Toshihiko Arita;Noriyoshi Manabe;Koichi Nakahara
研究了奈洛芬（一种非甾体抗炎药，BCS 2类）和芝麻素（一种水溶性差的木脂素）的纳米颗粒（NP）。通过应用新开发的配备有介电喷嘴的液体二氧化碳溶液的快速膨胀系统，在没有加热、表面活性剂和共溶剂的情况下获得了分离良好且精细的萘普生纳米颗粒（平均粒度（APS）= 46.9 nm）和芝麻素纳米颗粒（APS = 60.2 nm）。获得的萘普生和芝麻素NP具有大的表面/重量比，因此，它们显示出瞬间溶解到水中，直到比饱和浓度高约10%。此外，在研究中开发的技术在生产特别是药物NP方面具有很大的优势，因为通过该方法生产的NP既不包括有毒添加剂（特别是共溶剂和洗涤剂）也不包括热变性化合物。
Nanoparticles (NPs) of naproxen (a nonsteroidal anti-inflammatory drug, BCS Class 2) and sesamin (a poorly water-soluble lignan) were investigated. By applying a newly developed rapid expansion system of liquid carbon dioxide solutions equipped with a dielectric nozzle, well-separated and fine both naproxen NPs (averaged particle size (APS) = 46.9 nm) and sesamin NPs (APS = 60.2 nm) were obtained without heating, surfactants, and co-solvents. Obtained naproxen and sesamin NPs had large surface/weight ratio, therefore, they showed instant dissolution to water until about ten percent higher than the saturated concentrations. In addition, the technique developed in the study has big advantage on producing especially drug NPs because the NPs produced by the method never includes neither poisonous additives (especially co-solvents and detergents) nor thermally denatured compounds.
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