Effect of zinc-carnosine chelate compound (Z-103), a novel antioxidant, on acute gastric mucosal injury induced by ischemia-reperfusion in rats.
Effect of zinc-carnosine chelate compound (Z-103), a novel antioxidant, on acute gastric mucosal injury induced by ischemia-reperfusion in rats.
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新型抗氧化剂锌肌肽螯合化合物（Z-103）对缺血再灌注大鼠急性胃粘膜损伤的影响。
DOI：
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
M. Kondo
中科院分区：
文献类型：
--
作者：
T. Yoshikawa;Y. Naito;T. Tanigawa;T. Yoneta;M. Yasuda;S. Ueda;H. Oyamada;M. Kondo
本文研究了一种新型合成锌-肌肽螯合物锌N-（3-氨基丙酰）- l -组氨酸（Z-103）对大鼠胃黏膜缺血再灌注损伤的保护作用。用小钳夹住腹腔动脉30min，取下钳夹30min，对大鼠胃进行缺血再灌注损伤。Z-103对胃黏膜血流量的减少无明显影响。口服Z-103可显著抑制缺血再灌注后胃糜烂总面积的增加和胃黏膜脂质过氧化物的增加。此外，Z-103在体外对大鼠脑匀浆和肝微粒体的脂质过氧化有抑制作用。提示Z-103对缺血再灌注后胃粘膜损伤加重的保护作用可能与其抑制脂质过氧化作用有关。
The protective effect of a novel synthetic zinc-carnosine chelate compound, zinc N-(3-aminopropionyl)-L-histidine (Z-103), on the gastric mucosal injury induced by ischemia-reperfusion was studied in rats. Ischemia and reperfusion injury was produced on the rat stomach by applying a small clamp to the celiac artery for 30 min and by removal of the clamp for 30 min. The decrease in the gastric mucosal blood flow was not influenced by the treatment with Z-103. The increase in total area of the erosions on the stomach after ischemia-reperfusion and the increase in lipid peroxides in the gastric mucosa were significantly inhibited by the oral administration of Z-103. In addition, Z-103 inhibited lipid peroxidation of rat brain homogenate and liver microsome in vitro. These results suggest that the protective effect of Z-103 against the aggravation of gastric mucosal injury induced by ischemia-reperfusion may be due to its inhibitory effect on lipid peroxidation.
拦截有毒物质/诱变剂/致癌物：大自然的一些新策略。
DOI：
10.1007/978-1-4684-5182-5_14
发表时间：
1986
期刊：
Basic life sciences
影响因子：
--
作者：
Hartman,PE
通讯作者：
Hartman,PE
DOI：
10.1073/pnas.85.9.3175
发表时间：
1988-05-01
影响因子：
11.1
作者：
KOHEN, R;YAMAMOTO, Y;AMES, BN
通讯作者：
AMES, BN