Regulation of placental angiogenesis.
Regulation of placental angiogenesis.
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DOI：
10.1111/micc.12093
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发表时间：
2014-01
期刊：
影响因子：
--
通讯作者：
Zheng J
中科院分区：
文献类型：
--
作者：
Chen DB;Zheng J
基于对正常妊娠和异常妊娠胎盘血管生成的了解，利用胎盘血管生成作为开发妊娠并发症诊断工具和潜在治疗方法的靶点引起了人们的极大兴趣。尽管这些目标仍远未达到，但人们预计，在任何妊娠并发症中，治疗性血管生成要成功地恢复胎盘中成熟和功能性的血管网络，应该平衡两个互补的过程：(I)促进血管生成刺激新血管生长；(Ii)抗血管生成抑制血管过度生长。作为生理性血管生成的最佳模型，胎盘血管生成的研究不仅为更好地理解正常的胎盘内皮生物学，而且为开发妊娠并发症的诊断工具提供了重要的见解。这样的研究可能会发现新的促血管生成因子，用于治疗各种产科并发症或心力衰竭的组织损伤，或针对需要限制循环的癌症或视力丧失的抗血管生成因子。本文综述了正常胎盘血管生成的遗传学和分子机制，以及主要的血管生成因子血管内皮生长因子调控胎盘血管生成的信号机制，主要集中在胎盘内皮细胞。
Ample interest has been evoked in using placental angiogenesis as a target for the development of diagnosis tools and potential therapeutics for pregnancy complications based on the knowledge of placental angiogenesis in normal and aberrant pregnancies. Although these goals are still far from reach, one would expect that two complementary processes should be balanced for therapeutic angiogenesis to be successful in restoring a mature and functional vascular network in the placenta in any pregnancy complication: (i) pro-angiogenic stimulation of new vessel growth and (ii) anti-angiogenic inhibition of vessel overgrowth. As the best model of physiological angiogenesis, investigations of placental angiogenesis provide critical insights not only for better understanding of normal placental endothelial biology but also for the development of diagnosis tools for pregnancy complications. Such investigations will potentially identify novel pro-angiogenic factors for therapeutic intervention for tissue damage in various obstetric complications or heart failure or anti-angiogenic factors to target on cancer or vision loss in which circulation needs to be constrained. This review summarizes the genetic and molecular aspects of normal placental angiogenesis as well as the signaling mechanisms by which the dominant angiogenic factor vascular endothelial growth factor regulates placental angiogenesis with a focus on placental endothelial cells.
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