Decision flexibilities in autism spectrum disorder: an fMRI study of moral dilemmas.
Decision flexibilities in autism spectrum disorder: an fMRI study of moral dilemmas.
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DOI：
10.1093/scan/nsac023
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发表时间：
2022-10-03
影响因子：
4.2
通讯作者：
Fujino, Junya
中科院分区：
文献类型：
--
作者：
Tei, Shisei;Tanicha, Mizuki;Itahashi, Takashi;Aoki, Yuta Y.;Ohta, Haruhisa;Qian, Chenyu;Hashimoto, Ryu-Ichiro;Nakamura, Motoaki;Takahashi, Hidehiko;Kato, Nobumasa;Fujino, Junya
关键词：
人们在各种各样的环境中做出灵活的决定，以解决社会或道德冲突。自闭症谱系障碍（ASD）患者经常报告在这些行为中存在困难，这阻碍了在日常活动中改变策略或在沟通中调整观点的灵活性。然而，人们对这个问题的潜在机制还不够了解。本研究的目的是调查决策的灵活性ASD使用功能性磁共振成像任务，涉及识别和解决两种类型的道德困境：成本效益分析（CBA）和减轻不可避免的不当行为（MIM）。基于结果的评估会议评估了与会者将注重结果的结果与令人痛苦的有害行为相比较的情况，而基于结果的评估会议评估了他们将减轻刑事判决与同情遭受暴力或疾病的被告的情况相比较的情况。与典型发育组相比，ASD组的CBA相关灵活性的行为结果显著降低。在相应的CBA对比中，ASD组左侧额下回的激活较低。同时，在与MIM相关的灵活性方面，行为结果或大脑活动没有显著的组间差异。我们的研究结果增加了我们对ASD灵活决策的理解。
People make flexible decisions across a wide range of contexts to resolve social or moral conflicts. Individuals with autism spectrum disorder (ASD) frequently report difficulties in such behaviors, which hinders the flexibility in changing strategies during daily activities or adjustment of perspective during communication. However, the underlying mechanisms of this issue are insufficiently understood. This study aimed to investigate decision flexibility in ASD using a functional magnetic resonance imaging task that involved recognizing and resolving two types of moral dilemmas: cost–benefit analysis (CBA) and mitigating inevitable misconducts (MIM). The CBA session assessed the participants’ pitting of result-oriented outcomes against distressful harmful actions, whereas the MIM session assessed their pitting of the extenuation of a criminal sentence against a sympathetic situation of defendants suffering from violence or disease. The behavioral outcome in CBA-related flexibility was significantly lower in the ASD group compared to that of the typical development group. In the corresponding CBA contrast, activation in the left inferior frontal gyrus was lower in the ASD group. Meanwhile, in the MIM-related flexibility, there were no significant group differences in behavioral outcome or brain activity. Our findings add to our understanding of flexible decision-making in ASD.
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DOI：
10.1007/s00406-019-01071-4
发表时间：
2020-12-01
影响因子：
4.7
作者：
Fujino, Junya;Tei, Shisei;Takahashi, Hidehiko
通讯作者：
Takahashi, Hidehiko
DOI：
10.1073/pnas.1009396107
发表时间：
2010-10-05
影响因子：
11.1
作者：
Crockett, Molly J.;Clark, Luke;Robbins, Trevor W.
通讯作者：
Robbins, Trevor W.
影响因子：
6.8
作者：
D'Cruz AM;Mosconi MW;Ragozzino ME;Cook EH;Sweeney JA
通讯作者：
Sweeney JA
影响因子：
3.9
作者：
Buon, Marine;Dupoux, Emmanuel;Zalla, Tiziana
通讯作者：
Zalla, Tiziana
影响因子：
4.6
作者：
Fujino J;Fujimoto S;Kodaka F;Camerer CF;Kawada R;Tsurumi K;Tei S;Isobe M;Miyata J;Sugihara G;Yamada M;Fukuyama H;Murai T;Takahashi H
通讯作者：
Takahashi H