Immune recognition of Candida albicans beta-glucan by dectin-1.
Immune recognition of Candida albicans beta-glucan by dectin-1.
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DOI：
10.1086/523110
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发表时间：
2007-11-15
期刊：
影响因子：
--
通讯作者：
Kullberg BJ
中科院分区：
文献类型：
--
作者：
Gow NA;Netea MG;Munro CA;Ferwerda G;Bates S;Mora-Montes HM;Walker L;Jansen T;Jacobs L;Tsoni V;Brown GD;Odds FC;Van der Meer JW;Brown AJ;Kullberg BJ
β（1，3）-葡聚糖占酵母菌白色念珠菌细胞壁的40%。已显示dectin-1凝集素样受体识别真菌β（1，3）-葡聚糖并诱导先天性免疫应答。β-glucan-dectin-1通路在C.人类原代血细胞感染白色念珠菌的研究还没有得到证实。在这项研究中，我们证明了人外周血单核细胞和小鼠巨噬细胞产生的细胞因子依赖于dectin-1对β-葡聚糖的识别。C.白色念珠菌导致细胞壁表面的β-葡聚糖暴露，随后被dectin-1识别，而活酵母主要通过识别细胞表面甘露聚糖来刺激单核细胞。Dectin-1通过以下2种途径诱导细胞因子产生：Syk依赖性产生T辅助细胞（Th）2型抗炎细胞因子白细胞介素-10和Toll样受体-Myd 88依赖性刺激单核细胞衍生的促炎细胞因子，如肿瘤坏死因子-α。相反，C.白念珠菌不依赖于dectin-1对β-葡聚糖的识别。结果表明，C.白色念珠菌通过依赖或不依赖于dectin-1的不同途径诱导单核细胞衍生的和T细胞衍生的细胞因子的产生。
β(1,3)-glucans represent 40% of the cell wall of the yeast Candida albicans. The dectin-1 lectin-like receptor has shown to recognize fungal β(1,3)-glucans and induce innate immune responses. The importance of β-glucan-dectin-1 pathways for the recognition of C. albicans by human primary blood cells has not been firmly established. In this study we demonstrate that cytokine production by both human peripheral blood mononuclear cells and murine macrophages is dependent on the recognition of β-glucans by dectin-1. Heat killing of C. albicans resulted in exposure of β-glucans on the surface of the cell wall and subsequent recognition by dectin-1, whereas live yeasts stimulated monocytes mainly via recognition of cell-surface mannans. Dectin-1 induced cytokine production through the following 2 pathways: Syk-dependent production of the T-helper (Th) 2-type anti-inflammatory cytokine interleukin-10 and Toll-like receptor-Myd88-dependent stimulation of monocyte-derived proinflammatory cytokines, such as tumor necrosis factor-α. In contrast, stimulation of Th1-type cytokines, such as interferon-γ, by C. albicans was independent of the recognition of β-glucans by dectin-1. In conclusion, C. albicans induces production of monocyte-derived and T cell-derived cytokines through distinct pathways dependent on or independent of dectin-1.
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Dectin-1介导β-葡聚糖的生物学作用。
DOI：
10.1084/jem.20021890
发表时间：
2003-05-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Brown GD;Herre J;Williams DL;Willment JA;Marshall AS;Gordon S
通讯作者：
Gordon S
影响因子：
4.4
作者：
Jouault, Thierry;Behi, Miryam El Abed-El;Poulain, Daniel
通讯作者：
Poulain, Daniel
影响因子：
168.9
作者：
OBAYASHI, T;YOSHIDA, M;KAWAI, T
通讯作者：
KAWAI, T
DOI：
10.1007/bf01975039
发表时间：
1988-12-01
影响因子：
4.5
作者：
VANTWOUT, JW;LINDE, I;VANFURTH, R
通讯作者：
VANFURTH, R
影响因子：
4.4
作者：
Bellocchio, S;Montagnoli, C;Romani, L
通讯作者：
Romani, L