A review: inflammatory process in Alzheimer's disease, role of cytokines.
A review: inflammatory process in Alzheimer's disease, role of cytokines.
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DOI：
10.1100/2012/756357
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发表时间：
2012
影响因子：
--
通讯作者：
Morillas-Ruiz JM
中科院分区：
文献类型：
--
作者：
Rubio-Perez JM;Morillas-Ruiz JM
阿尔茨海默病（AD）是迄今为止最常见的神经退行性疾病。神经病理学标志是β-淀粉样蛋白（Aβ）斑块和神经纤维缠结，但炎症过程在AD的发病机制中具有基础作用。与AD神经炎症相关的炎症组分包括脑细胞如小胶质细胞和星形胶质细胞、补体系统以及细胞因子和趋化因子。细胞因子在AD的炎症和抗炎过程中起关键作用。炎症过程发生的一个重要因素是白细胞介素（IL）-1的过度表达，其产生恶性循环中的许多反应，导致功能障碍和神经元死亡。神经炎症中的其他重要细胞因子是IL-6和肿瘤坏死因子（TNF）-α。相比之下，其他细胞因子如IL-1受体拮抗剂（IL-1 ra）、IL-4、IL-10和转化生长因子（TGF）-β可以抑制促炎细胞因子的产生及其作用，从而保护大脑。在流行病学研究中观察到，非甾体抗炎药（NSAID）治疗可降低AD的风险。不幸的是，非甾体抗炎药在AD患者中的临床试验并不是很有成效。促炎反应可以通过多酚来对抗。这些天然化合物的补充可能为这种大脑疾病提供新的治疗方法。
Alzheimer's disease (AD) is the most common neurodegenerative disorder to date. Neuropathological hallmarks are β-amyloid (Aβ) plaques and neurofibrillary tangles, but the inflammatory process has a fundamental role in the pathogenesis of AD. Inflammatory components related to AD neuroinflammation include brain cells such as microglia and astrocytes, the complement system, as well as cytokines and chemokines. Cytokines play a key role in inflammatory and anti-inflammatory processes in AD. An important factor in the onset of inflammatory process is the overexpression of interleukin (IL)-1, which produces many reactions in a vicious circle that cause dysfunction and neuronal death. Other important cytokines in neuroinflammation are IL-6 and tumor necrosis factor (TNF)-α. By contrast, other cytokines such as IL-1 receptor antagonist (IL-1ra), IL-4, IL-10, and transforming growth factor (TGF)-β can suppress both proinflammatory cytokine production and their action, subsequently protecting the brain. It has been observed in epidemiological studies that treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) decreases the risk for developing AD. Unfortunately, clinical trials of NSAIDs in AD patients have not been very fruitful. Proinflammatory responses may be countered through polyphenols. Supplementation of these natural compounds may provide a new therapeutic line of approach to this brain disorder.
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影响因子：
5.3
作者：
Afagh, A;Cummings, BJ;Tenner, AJ
通讯作者：
Tenner, AJ
影响因子：
2.4
作者：
Blasko, I;Lederer, W;Humpel, C
通讯作者：
Humpel, C
DOI：
10.3109/10715768709065294
发表时间：
1987-01-01
期刊：
Free radical research communications
影响因子：
--
作者：
Bors, W;Saran, M
通讯作者：
Saran, M
影响因子：
5.7
作者：
Botchkina, GI;Meistrell, ME;Tracey, KJ
通讯作者：
Tracey, KJ
影响因子：
9.9
作者：
Aisen, PS;Davis, KL;Thal, LJ
通讯作者：
Thal, LJ