Equine osteoarthritis: Strategies to enhance mesenchymal stromal cell-based acellular therapies.
Equine osteoarthritis: Strategies to enhance mesenchymal stromal cell-based acellular therapies.
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DOI：
10.3389/fvets.2023.1115774
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发表时间：
2023
影响因子：
3.2
通讯作者：
中科院分区：
文献类型：
--
作者：
骨关节炎（OA）是一种退行性疾病，最终导致关节软骨完全退化。关节软骨具有有限的内在自我修复能力，迄今为止，还没有治愈性治疗OA的方法。人类和马具有相似的关节软骨和OA病因。因此，在一个健康方法的背景下，马OA治疗的进展可以帮助改善马的健康，也可以构成人类医学的临床前研究。此外，马OA影响马的福利，并导致马产业的重大经济损失。在过去的几年中，间充质基质细胞（MSC）的免疫调节和软骨再生潜力已被证明，但也引起了一些关注。然而，MSC的大部分治疗特性包含在其分泌组中，特别是在其细胞外囊泡（EV）中，这是一种有前途的脱细胞治疗途径。从组织来源到体外培养方法，必须考虑各个方面来优化MSC分泌组用于OA治疗的潜力。MSC的免疫调节和再生特性也可以通过重建促炎环境来模拟体内病理环境来增强，但更不寻常的方法也值得研究。总而言之，这些策略对于开发适合于OA管理的基于MSC分泌组的疗法具有巨大潜力。这篇小综述的目的是调查马OA MSC分泌组研究的最新进展。
Osteoarthritis (OA) is a degenerative disease that eventually leads to the complete degradation of articular cartilage. Articular cartilage has limited intrinsic capacity for self-repair and, to date, there is no curative treatment for OA. Humans and horses have a similar articular cartilage and OA etiology. Thus, in the context of a One Health approach, progress in the treatment of equine OA can help improve horse health and can also constitute preclinical studies for human medicine. Furthermore, equine OA affects horse welfare and leads to significant financial losses in the equine industry. In the last few years, the immunomodulatory and cartilage regenerative potentials of mesenchymal stromal cells (MSCs) have been demonstrated, but have also raised several concerns. However, most of MSC therapeutic properties are contained in their secretome, particularly in their extracellular vesicles (EVs), a promising avenue for acellular therapy. From tissue origin to in vitro culture methods, various aspects must be taken into consideration to optimize MSC secretome potential for OA treatment. Immunomodulatory and regenerative properties of MSCs can also be enhanced by recreating a pro-inflammatory environment to mimic an in vivo pathological setting, but more unusual methods also deserve to be investigated. Altogether, these strategies hold substantial potential for the development of MSC secretome-based therapies suitable for OA management. The aim of this mini review is to survey the most recent advances on MSC secretome research with regard to equine OA.
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影响因子：
5.6
作者：
Desancé M;Contentin R;Bertoni L;Gomez-Leduc T;Branly T;Jacquet S;Betsch JM;Batho A;Legendre F;Audigié F;Galéra P;Demoor M
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通讯作者：
Gonzalez, Manuel A.
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通讯作者：
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