Accurate automatic estimation of total intracranial volume: a nuisance variable with less nuisance.
Accurate automatic estimation of total intracranial volume: a nuisance variable with less nuisance.
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DOI：
10.1016/j.neuroimage.2014.09.034
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发表时间：
2015-01-01
期刊：
影响因子：
5.7
通讯作者：
Ridgway GR
中科院分区：
文献类型：
--
作者：
Malone IB;Leung KK;Clegg S;Barnes J;Whitwell JL;Ashburner J;Fox NC;Ridgway GR
颅内总体积(TIV/ICV)是脑和脑区域体积分析的重要协变量，特别是在神经退行性疾病的研究中，它可以作为疾病前最大脑体积的替代指标。黄金标准的方法是手动描绘脑部扫描，但这需要训练有素的操作员仔细工作。我们评估了用于TIV测量的统计参数映射12(SPM12)自动分割代替手动分割，并将其与SPM8和Freesurfer 5.3.0进行了比较。对于288名阿尔茨海默病多中心临床试验参与者的T1加权磁共振成像，我们发现SPM12TIV与手动TIV之间有很高的相关性(R2=0.940，95%可信区间(0.924，0.953))，平均差异很小(SPM1240.4±35.4万亿毫升比手动TIV低，相当于研究中总平均TIV的2.8%)。与手动测量的相关性(使用TIV作为协变量时的关键方面)显著高于SPM8(R2=0.577 CI(0.500，0.644))或自由冲浪(R2=0.801 CI(0.744，0.843))。这些结果表明，即使在具有挑战性的多中心和存在神经退行性病变的情况下，SPM12 TIV估计也可以替代劳动密集型手动估计。我们还简要讨论了针对TIV进行调整的统计建模方法的一些方面。对来自多台扫描仪的288个T1磁共振图像进行手动分割，计算颅内体积。我们将SPM12与目前估计颅内体积的方法进行比较。SPM12与人工测量相关性很高，偏倚很小。新的自动音量测量可以更准确地控制头部大小的变化。
Total intracranial volume (TIV/ICV) is an important covariate for volumetric analyses of the brain and brain regions, especially in the study of neurodegenerative diseases, where it can provide a proxy of maximum pre-morbid brain volume. The gold-standard method is manual delineation of brain scans, but this requires careful work by trained operators. We evaluated Statistical Parametric Mapping 12 (SPM12) automated segmentation for TIV measurement in place of manual segmentation and also compared it with SPM8 and FreeSurfer 5.3.0. For T1-weighted MRI acquired from 288 participants in a multi-centre clinical trial in Alzheimer's disease we find a high correlation between SPM12 TIV and manual TIV (R2 = 0.940, 95% Confidence Interval (0.924, 0.953)), with a small mean difference (SPM12 40.4 ± 35.4 ml lower than manual, amounting to 2.8% of the overall mean TIV in the study). The correlation with manual measurements (the key aspect when using TIV as a covariate) for SPM12 was significantly higher (p < 0.001) than for either SPM8 (R2 = 0.577 CI (0.500, 0.644)) or FreeSurfer (R2 = 0.801 CI (0.744, 0.843)). These results suggest that SPM12 TIV estimates are an acceptable substitute for labour-intensive manual estimates even in the challenging context of multiple centres and the presence of neurodegenerative pathology. We also briefly discuss some aspects of the statistical modelling approaches to adjust for TIV. 288 T1 MRI from multiple scanners were manually segmented for intracranial volume. We compare SPM12 with the current methods of estimating intracranial volume. SPM12 shows a very high correlation with manual measures and little bias. Newer automated volume measures are more accurate controls for head size variation.
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