Lower sexual interest in postpartum women: relationship to amygdala activation and intranasal oxytocin.
Lower sexual interest in postpartum women: relationship to amygdala activation and intranasal oxytocin.
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DOI：
10.1016/j.yhbeh.2012.10.007
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发表时间：
2013-01
影响因子：
3.5
通讯作者：
Heiman, Julia R.
中科院分区：
文献类型：
--
作者：
Rupp, Heather A.;James, Thomas W.;Ketterson, Ellen D.;Sengelaub, Dale R.;Ditzen, Beate;Heiman, Julia R.
与怀孕前相比，产后女性的神经内分泌特征和社会行为发生了显着变化。做母亲的一个常见经历是性欲下降。尽管与分娩相关的生活方式和周围生理变化可能会降低女性的性兴趣，但我们假设女性对性和婴儿刺激的神经反应也存在激素介导的变化，从而改变了生殖优先顺序。我们预测，与未产妇相比，产后女性对性唤起刺激的杏仁核激活会受到抑制，并且通过鼻内催产素给药而改变。为了测试这一点，我们使用功能磁共振成像测量了 29 名产后和 30 名未产妇对性唤起图片、婴儿图片和中性图片的杏仁核激活情况。一半的女性在扫描前接受了一剂外源性催产素。正如预测的那样，与产后女性相比，未生育过的女性主观上认为性图片更能唤起性欲，而婴儿图片则不那么唤起性欲。然而，接受鼻催产素喷雾剂的未产妇认为婴儿照片与产后妇女一样令人兴奋。与未产妇相比，产后女性的右侧杏仁核对性、婴儿和中性图像的反应较低，表明右侧杏仁核对分娩时引起性兴奋的图像的反应普遍下降。鼻喷雾剂应用对右侧杏仁核的激活没有差异。因此，产后女性似乎会经历性兴趣下降，这可能是杏仁核对唤起刺激的反应性普遍下降的一个特征。
During the postpartum period, women experience significant changes in their neuroendocrine profiles and social behavior compared to before pregnancy. A common experience with motherhood is a decrease in sexual desire. Although the lifestyle and peripheral physiological changes associated with parturition might decrease a woman’s sexual interest, we hypothesized that there are also hormone-mediated changes in women’s neural response to sexual and infant stimuli with altered reproductive priorities. We predicted that amygdala activation to sexually arousing stimuli would be suppressed in postpartum versus nulliparous women, and altered with intranasal oxytocin administration. To test this, we measured amygdala activation using fMRI in response to sexually arousing pictures, infant pictures, and neutral pictures in 29 postpartum and 30 nulliparous women. Half of the women received a dose of exogenous oxytocin before scanning. As predicted, nulliparous women subjectively rated sexual pictures to be more arousing, and infant pictures to be less arousing, than did postpartum women. However, nulliparous women receiving the nasal oxytocin spray rated the infant photos as arousing as did postpartum women. Right amygdala activation was lower in postpartum versus nulliparous women in response to sexual, infant, and neutral images, suggesting a generalized decrease in right amygdala responsiveness to arousing images with parturition. There was no difference in right amygdala activation with nasal spray application. Postpartum women therefore appear to experience a decrease in sexual interest possibly as a feature of a more generalized decrease in amygdala responsiveness to arousing stimuli.
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影响因子：
1.8
作者：
Connolly, AM;Thorp, J;Pahel, L
通讯作者：
Pahel, L
影响因子：
3.6
作者：
De Judicibus, MA;McCabe, MP
通讯作者：
McCabe, MP
影响因子：
1.8
作者：
Baksu, Basak;Davas, Inci;Varolan, Ahmet
通讯作者：
Varolan, Ahmet
DOI：
10.1111/j.1552-6909.1986.tb01369.x
发表时间：
1986-01-01
期刊：
Journal of obstetric, gynecologic, and neonatal nursing : JOGNN
影响因子：
--
作者：
Fischman, S H;Rankin, E A;Lenz, E R
通讯作者：
Lenz, E R
影响因子：
3.6
作者：
Hyde, JS;DeLamater, JD;Byrd, JM
通讯作者：
Byrd, JM