Blurring the edges in vertebrate sex determination.
Blurring the edges in vertebrate sex determination.
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DOI：
10.1016/j.gde.2008.11.004
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发表时间：
2008-12
影响因子：
4
通讯作者：
Capel, Blanche
中科院分区：
文献类型：
--
作者：
Barske, Lindsey A.;Capel, Blanche
脊椎动物的性别是由遗传或环境信号决定的。这些信号在性腺内启动分子级联和细胞-细胞相互作用，导致雄性或雌性命运的通过。以前，遗传和环境为基础的机制被认为是不同的，但这一想法正在褪色的结果，意外发现一致的遗传和热影响在单一物种。随着性别决定机制之间频繁转换的系统发育证据的积累，这些研究结果表明，遗传和环境性别决定实际上代表了一个连续体上的点，而不是离散的类别，种群可能会向一个方向或另一个方向转变，以应对突变或不断变化的生态条件。阐明了小鼠性别决定的潜在分子基础，产生了相互拮抗的信号通路和反馈调节环的非线性模型。该系统将高度响应上游初级信号的变化，并可能为不同性别决定方法之间的快速进化和过渡提供基础。
Sex in vertebrates is determined by genetic- or environmentally-based signals. These signals initiate molecular cascades and cell-cell interactions within the gonad that lead to the adoption of the male or female fate. Previously, genetic- and environmentally-based mechanisms were thought to be distinct, but this idea is fading as a result of the unexpected discovery of coincident genetic and thermal influences within single species. Together with accumulating phylogenetic evidence of frequent transitions between sex-determining mechanisms, these findings suggest that genetic and environmental sex determination actually represent points on a continuum rather than discrete categories, and that populations may shift in one direction or the other in response to mutations or changing ecological conditions. Elucidation of the underlying molecular basis of sex determination in mice has yielded a bistable model of mutually antagonistic signaling pathways and feedback regulatory loops. This system would be highly responsive to changes in the upstream primary signal and may provide a basis for the rapid evolution of and transitions between different methods of sex determination.
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DOI：
10.1073/pnas.0702581104
发表时间：
2007-10-16
影响因子：
11.1
作者：
Kim, Yuna;Bingham, Nathan;Capel, Blanche
通讯作者：
Capel, Blanche
影响因子：
3.5
作者：
Chassot, Anne-Amandine;Ranc, Fariba;Chaboissier, Marie-Christine
通讯作者：
Chaboissier, Marie-Christine
DOI：
10.1016/s1532-0456(01)00267-8
发表时间：
2001-12-01
影响因子：
3.9
作者：
Baroiller, JF;D'Cotta, H
通讯作者：
D'Cotta, H
影响因子：
2.7
作者：
Bagheri-Fam, Stefan;Sim, Helena;Harley, Vincent R.
通讯作者：
Harley, Vincent R.
影响因子：
0.9
作者：
Matsuda, M;Sato, T;Sakaizumi, M
通讯作者：
Sakaizumi, M